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Iranian Journal of Pathology، جلد ۱۲، شماره ۲، صفحات ۱۵۸-۱۶۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The HER-2 as a Target Gene of Curcumin to Protect Hepatocytes Against the Arsenic-induced Carcinoma in Mice
چکیده انگلیسی مقاله Background & objective: The HER-2 gene is an important on co protein overexpressed in many types of cancers. The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFκB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC). Methods: In the current study, 40 male NMRI (Naval Medical Research Institute) mice were divided into 4 groups of 10 as follow: Group1 (control group) only received 5 mL/kg corn oil, group 2 (poisoned group) received 30 mg/L arsenic (As2O3) dissolved in water, group3 (curcumin treated), and group 4 (curcumin and arsenic treated) received 10 to 20mg/5mL/kg for 60 days. Once experimental period was completed, liver samples were collected. The analysis of the gene expression was performed by real-time polymerase chain reaction (PCR) technique. Results: Gene expression analysis showed that curcumin had significantly downregulated the activity of HER-2, in poisoned mice. Conclusion: According to the current study results, it could be concluded that curcumin has the inhibitory potential toward HER-2-overexpressed HCC.
کلیدواژه‌های انگلیسی مقاله Her2, Hepatocellular Carcinoma, Curcumin, Arsenic
نویسندگان مقاله مهدی احدی |
dept. of biology, faculty of biological sciences, parand branch, islamic azad university, parand, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

وحید ناصح |
dept. of biology, faculty of biological sciences, parand branch, islamic azad university, parand, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی پرند (Islamic azad university of parand)

مسعود صالحی پور |
dept. of biology, faculty of biological sciences, parand branch, islamic azad university, parand, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی پرند (Islamic azad university of parand)

نشانی اینترنتی http://ijp.iranpath.org/article_24874_ecd6c3150b00d78da46e734b02ea618b.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/194/article-194-401475.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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