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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۳، صفحات ۱۷۶-۱۸۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Stereospecific pharmacokinetic characterization of liquiritigenin in the rat
چکیده انگلیسی مقاله Liquiritigenin is a chiral flavonoid present in licorice and other medicinal plants. The nature of its biological fate with respect to the individual enantiomers has not been examined. In this study, we characterize, for the first time, the stereoselective pharmacokinetics of liquiritigenin. Liquiritigenin was intravenously (20 mg/kg) and orally (50 mg/kg) administered to male Sprague-Dawley rats (n = 4 per route of administration). Concentrations in serum and urine were characterized via stereospecific reversed-phase, isocratic HPLC method with UV detection. Serum concentrations were quantified but rapidly fell to undetectable levels. S-liquiritigenin showed a short half-life (0.25-0.54 h), while a better estimation of half-life (26-77 h) and other pharmacokinetic parameters was observed using urinary data. The flavonoid is predominantly excreted via non-renal routes (f e values of 0.16-3.46 %), and undergoes rapid and extensive phase II metabolism. Chiral differences in the chemical structure of the compound result in some pharmacokinetic differences. Serum concentrations rapidly declined, making modeling difficult. S-liquiritigenin showed an increased urinary half-life.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله samaa alrushaid | samaa alrushaid
1college of pharmacy, faculty of health sciences, university of manitoba, winnipeg, mb, canada.


نیل m دیویس | neal m davies
2faculty of pharmacy and pharmaceutical sciences, university of alberta, edmonton, ab, canada.


stephanie e رودریگویز | stephanie e martinez
3college of veterinary medicine, washington state university, pullman, washington, united states.


casey l sayre | casey l sayre
4college of pharmacy, roseman university of health sciences, south jordan, utah, united states.
نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1759
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-402742.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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