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Iranian Journal of Pathology، جلد ۱۲، شماره ۳، صفحات ۲۵۷-۲۶۴
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عنوان انگلیسی Evaluation of Association Between the Serum Levels of MMP-9 and MMP-9/TIMPs With Soluble Forms of Selectins and Itching Induced by Sulfur Mustard
چکیده انگلیسی مقاله Background & objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP)-9 and their endogenous inhibitors, and serum levels of soluble forms of selectins (sL-, sP-, and sE-selectins) as adhesion molecules involved in the development of different inflammatory reactions. Methods: Serum levels of MMP-9, MMP-9/ tissue inhibitors of metalloproteinases (TIMPs), and selectins were measured by the enzyme-linked immunosorbent assay (ELISA), and compared between the groups (n=368) with and without itching, and matched control groups (n=126). Results: Serum levels of MMP-9 were significantly higher in the SM exposed group with itching, compared with that of the group without itching (medians: 894 and 624 pg/mL respectively; P-value =0.034). There was no relationship between the serum levels of MMP-9/TIMP-1, MMP-9/TIMP-2, MMP-9/TIMP-4, and itching in the patients exposed to SM. Median serum levels of sE- and sL-selectins in the exposed group with itching were higher than those of the exposed group without itching. These differences were statistically insignificant (P-values =0.084 and 0.095, respectively). Conclusion: According to the results of the current study, the increased serum levels of MMP-9 and selectins 20 years after exposure may play role in the pathogenesis and persistence of SM-induced itching in the exposed individuals.
کلیدواژه‌های انگلیسی مقاله Mustard Gas, Pruritus, MMP-9, MMP-9/TIMPs, Selectins
نویسندگان مقاله نیره عسکری |
dept. of biology, faculty of basic sciences, shahid bahonar university of kerman, kerman, iran
سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

طوبی غضنفری |
immunoregulation research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

محمد مهدی نقی زاده | mohammad mehdi
immunoregulation research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

اطهر معین |
immunoregulation research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

علی خامسی پور |
center for research and training in skin diseases and leprosy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهریار پورفرزام |
immunoregulation research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

زهیر محمد حسن | zuhair mohammad
dept. of immunology, tarbiat moddares university, tehran, iran

نشانی اینترنتی http://ijp.iranpath.org/article_25646_11ba5471ebe41871523e421873ee1f20.pdf
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