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Middle East Journal of Cancer، جلد ۸، شماره ۳، صفحات ۱۵۵-۰
عنوان فارسی
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عنوان انگلیسی Diagnostic Accuracy of Intraoperative Frozen Section and Causes of Error in Ovarian Epithelial Tumors: An Institutional Experience
چکیده انگلیسی مقاله Background: Ovarian cancer is the second most common type of female genital tract malignancy. Treatment planning differs for benign, borderline, and malignant subtypes of surface epithelial tumors and depends on accurate histopathological diagnosis. The aim of this study is to determine the accuracy and causes for error in intraoperative diagnosis of ovarian surface epithelial tumors. Methods: In this retrospective study, we analyzed all cases of ovarian surface epithelial tumors referred to the Pathology Department of our hospital from April 2010 to December 2015. We considered the final diagnosis as the gold standard and determined the accuracy, sensitivity, specificity, positive predictive value, negative predictive value, underdiagnosis and overdiagnosis for each group of benign, borderline, and malignant tumors. An expert pathologist blinded to the diagnosis reviewed patients’ frozen and permanent slides and categorized causes of error into misinterpretation, sampling, and technical errors. Results: We assessed 220 patients’ slides (96 benign, 66 borderline, and 58 malignant tumors). The accuracy of the frozen section was: 98% in benign, 80.3% in borderline and 67.2% in malignant tumors. The frozen sections had a sensitivity of 97.9% for benign tumors and a sensitivity of 67.2% and specificity of 100% for malignant tumors. Borderline tumors had a sensitivity of 91% and specificity of 88.4%. Mucinous borderline tumors comprised the more frequent uncertain and underdiagnosed cases. The main cause for error in this group was sampling error. In malignant neoplasms, 15.5% were reported to be at least borderline. Technical issues were the cause of difficulty in interpretation. In the benign category, cystadenofibroma could be misinterpreted as a borderline malignancy. Conclusion: Frozen section is an accurate, specific method for diagnosis of benign and malignant tumors. In the borderline category, the results should be interpreted with caution.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فاطمه نیلی | fatemeh nili
department of pathology, cancer institute, imam khomeini hospital complex, tehran university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

وحید سلیمانی | vahid soleimani
department of pathology, cancer institute, imam khomeini hospital complex, tehran university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهناز جهان بین | behnaz jahanbin
department of pathology, cancer institute, imam khomeini hospital complex, tehran university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید سیامک جلال الحسینی | seyed siamak jalal alhoseini
department of pathology, cancer institute, imam khomeini hospital complex, tehran university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علیرضا قنادان | alireza ghanadan
department of pathology, cancer institute, imam khomeini hospital complex, tehran university of medical sciences, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://mejc.sums.ac.ir/index.php/mejc/article/view/549
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-411477.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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