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Basic and Clinical Neuroscience، جلد ۸، شماره ۳، صفحات ۲۱۳-۲۲۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats
چکیده انگلیسی مقاله Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain. Methods: Orofacial pain was induced by subcutaneous intra lip injection of capsaicin (100 μg). CA1 administration of orexin A and its selective antagonist (SB-334867-A) were performed 20 minutes prior to capsaicin injection. Learning and spatial memory performances were assessed by Morris Water Maze (MWM) task. Results: Capsaicin treated rats showed impairment in spatial learning and memory. In addition, pretreatment with orexin A (20 and 40 nM/rat) significantly attenuated learning and memory impairment in capsaicin-treated rats. Conversely, blockage of OX1R via SB-334867-A (40 and 80 nM/rat) significantly exaggerated learning and memory loss in capsaicin-treated rats. Conclusion: The obtained results indicated that CA1 OX1R may be involved in modulation of capsaicin –induced spatial learning and memory impairment.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله راضیه کوشکی | razieh kooshki
shahid bahonar university of kerman

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

مهدی عباس نژاد | mehdi abbasnejad
shahid bahonar university of kerman

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

سعید اسماعیلی ماهانی | saeed esmaeili mahani
shahid bahonar university of kerman

سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)

مریم ریوف | maryam raoof
department of endodontics, school of dentistry, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-906-1&slc_lang=en&sid=en
فایل مقاله دریافت فایل مقاله
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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