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Iranian Journal of Public Health، جلد ۴۶، شماره ۷، صفحات ۹۰۶-۹۱۶
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عنوان انگلیسی The Role of NT-proBNP in the Diagnosis of Ventricular Arrhythmias in Patients with Systemic
چکیده انگلیسی مقاله Background: In patients with systemic sclerosis, NT-proBNP is a useful diagnostic marker for pulmonary hypertension and ventricular dysfunction, with important prognostic significance. The aim of this study was to assess the relationship between the NT-proBNP levels and the presence and severity of ventricular arrhythmias in patients with scleroderma. Methods: Forty consecutive patients with a diagnostic of systemic sclerosis according to the EULAR criteria admitted at the Rheumatology Clinic of Cluj-Napoca, Romania, from Jan 2014 to Apr 2014 were enrolled. Patients underwent a 12-lead ECG and a 24-hour Holter ECG monitoring for ventricular arrhythmias evaluation. Blood sample testing (including NT-proBNP level measurements), echocardiography, spirometry, chest X-ray and, when considered appropriate, high-resolution chest CT were performed. Results: Sixty percent of patients (n=24) had abnormal NT-proBNP serum levels (>125 pg/ml) and 10 patients had >100 PVC /24 h. There was a statistically significant correlation between the NT-proBNP levels and the total number of premature ventricular contractions (PVC) (r=0.445, P =0.006), total number of isolated PVC (r=0,493, P =0.002), total number of ventricular couplets (r=0.379, P =0.021) and the number of PVC morphologies (r=0.501, P =0.002). The presence of an NT-proBNP serum level >287 pg/ml had a sensitivity of 55% and a specificity of 93% in predicting the presence of complex ventricular arrhythmias on 24-hour Holter ECG monitoring. Conclusion: NT-proBNP levels could become a useful ventricular arrhythmia marker for assessing the arrhythmic risk in patients with systemic sclerosis.
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نویسندگان مقاله lucian muresan | lucian muresan


آنا petcu | ana petcu


crina muresan | crina muresan


mirela rinzis | mirela rinzis


جبراییل gusetu | gabriel gusetu


دانا پوپ | dana pop


dumitru zdrenghea | dumitru zdrenghea


simona rednic | simona rednic


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/10388
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-412246.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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