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Iranian Journal of Blood and Cancer، جلد ۹، شماره ۲، صفحات ۳۷-۴۳
عنوان فارسی Brain MRI Findings in Children with Acute Lymphoblastic Leukemia
چکیده فارسی مقاله Background: Patients with leukemia are facing more complications in order to achieve longer survival. We aimed to evaluate the frequency of central nervous system abnormalities (CNS) on MRI of children with acute lymphoblastic leukemia (ALL). Methods: Sixty-six children with diagnosis of ALL aged 2-18 years were recruited. Non-contrast sequences of brain MRI in addition to diffusion weighted imaging of brain were obtained with 1.5 T (Siemens medical system) scanners in their maintenance phase of treatment. The age of onset, type of leukemia, protocol of treatment, and elapsed time from diagnosis were recorded. Chi-square test was used to compare the groups and t-test was used to evaluate the effect of not normally distributed variables. Results: 19 (28.8%) had abnormal CNS findings identified on MRI images including: nonspecific white matter high signal intensity in flair images with normal DWI, white matter ischemia proved on DWI, generalized brain atrophy, isolated mild enlargement of lateral ventricle and extracerebral complications including sinus thrombosis and sinusitis. Brain abnormalities were correlated with leukemia type, chemotherapy protocol and radiotherapy (P=0.006, 0.036, and 0.01, respectively). Conclusion: The wide spectrum of CNS abnormalities that were observed in children with ALL showed correlation with treatment methods and type of leukemia in this study. Combination of radiation therapy and chemotherapy increased CNS complications. Among extracerebral complications, dural sinus thrombosis proved by MRV was seen more frequently in T-cell leukemia patients treated with multiple high doses of the chemotherapy agent “L-asparaginase”. Since some neurological complications of leukemia are treatable, early diagnosis sounds essential.
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عنوان انگلیسی Post-Treatment Cerebral and Extracerebral Brain MRI Findings in Children with Acute Lymphoblastic Leukemia
چکیده انگلیسی مقاله Background and objectives: Patients with leukemia are facing more post-treatment complications despite longer survival. This study aimed to evaluate the frequency of treatment-related abnormalities on MRI of patients with leukemia. Materials and methods: Sixty-six children with diagnosis of acute lymphoblastic leukemia with the age range of 2-18 years were recruited. Non-contrast sequences of brain MRI in addition to diffusion weighted imaging of brain were obtained with 1.5 T (Siemens medical system) scanners. The age of onset, type of leukemia, protocol of treatment, and elapsed time from diagnosis were recorded. Chi-square test was used to compare the groups and t-test was used to evaluate the effect of not normally distributed variables. Results: Nineteen patients (28.8%) had treatment-related CNS findings identified on MRI images including: nonspecific white matter high signal intensity in flair images with normal DWI, white matter ischemia proved on DWI, generalized brain atrophy, isolated mild enlargement of lateral ventricle and extra-cerebral complications including sinus thrombosis and sinusitis. Brain abnormalities were correlated with leukemia type, chemotherapy protocol, and radiotherapy (P value= 0.006, 0.036, 0.01, respectively). Conclusion: The wide spectrum of CNS abnormalities that occur after treatment of leukemia were related to treatment methods and type of leukemia. Combination of radiation and chemotherapy increased CNS complications. Among extra cerebral complications, dural sinus thrombosis proved by MRV was seen more frequently in T-cell leukemia patients who were treated with multiple high doses of the chemotherapy agent “L-asparaginase”. Since some neurologic complications of leukemia are treatable, early diagnosis is essential. 
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نویسندگان مقاله کارملا کمالی | karmella kamali
assistant professor of radiology, radiology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

رضا تقوی نسب | reza taghavinasab
resident of radiology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سزانه حق پناه | sezaneh haghpanah
assistant professor of community medicine, hematology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمدرضا بردبار | mohammadreza bordbar
associate professor of pediatric hematology-oncology, hematology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

پارسا کمالی پور | parsa kamalipour
medical student, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-275-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/98/article-98-413209.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده Pediatric Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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