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Acta Medica Iranica، جلد ۵۵، شماره ۵، صفحات ۲۹۷-۳۰۳
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عنوان انگلیسی Association of Human Methionine Synthase-A2756G Transition With Prostate Cancer: A Case-Control Study and in Silico Analysis
چکیده انگلیسی مقاله Methionine synthase (MTR) is one of the key enzymes of folate pathway, which play a key role in the construction, repair, and methylation of DNA. In this study, an association of MTR A2756G gene transition with prostate cancer in men populations of Kashan-Iran was investigated by a case-control study and an in silico analysis. The 200 samples including 100 patients with prostate cancer, as case group and 100 healthy men, as control group included in this study. MTR -A2756G genotyping was performed by PCR-RFLP technique. Some in silico tools used to evaluate the effects of A2756G transition on the structure and function of MTR. Results showed that the AG genotype (OR: 2.4014, 95% CI: 1.3216-4.3636, P =0.0040), and GG genotype (OR: 3.6324, 95% CI: 1.2629-10.4475, P =0.0167) and G allele (OR: 2.0120, 95% CI: 1.3098-3.0905, P =0.0014) were associated with prostate cancer. In silico analysis showed that polymorphisms of the enzyme protein might change properties of MTR such as relative mutability and flexibility, which leads to alteration of stability and function of the enzyme. Based on the results, an MTR- A2756G polymorphism which changes activity and stability of the methionine synthase associated with prostate cancer in men. It is a preliminary study and is presenting data for future comprehensive study for making a clinical conclusion that this gene transition is a biomarker for susceptibility to prostate cancer.
کلیدواژه‌های انگلیسی مقاله Prostate cancer,MTR gene,A2756G transition,PCR-RFLP
نویسندگان مقاله آرزو ابراهیمی | arezou ebrahimi
department of biology, faculty of sciences, islamic azad university, damghan branch, damghan, iran. and department of molecular and cell biology, faculty of basic sciences, university of mazandaran, babolsar, iran.

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

اباصلت حسین زاده زاده | abasalt hosseinzadeh colagar
department of molecular and cell biology, faculty of basic sciences, university of mazandaran, babolsar, iran.

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

محمد کریمیان | mohammad karimian
department of biology, faculty of sciences, islamic azad university, damghan branch, damghan, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5801
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-415948.pdf
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زبان مقاله منتشر شده en
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