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مجله پزشکی ارومیه، جلد ۲۸، شماره ۴، صفحات ۲۴۵-۲۵۱
عنوان فارسی Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran
چکیده فارسی مقاله

Background & Aims: To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).

Materials & Methods: In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

Results: Investigation of the association of p.Gly119Arg polymorphism in CFI gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).

Conclusion: Our result show that p.Gly119Arg polymorphism of the CFI gene is unrelated to the susceptibility to AMD in Northwest of Iran.
کلیدواژه‌های فارسی مقاله AMD ، پلی مورفیسم ،ژن CFI
عنوان انگلیسی Association of CFI gene polymorphism with age related macular degeneration in Northwest of Iran
چکیده انگلیسی مقاله

Background & Aims: To investigate the association of CFI p.Gly119Arg polymorphism with Age-related macular degeneration (AMD).

Materials & Methods: In this case-control study, the association of p.Gly119Arg polymorphism in CFI gene was investigated in 65 patients suffering from AMD and150 healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from Northwest of Iran. Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

Results: Investigation of the association of p.Gly119Arg polymorphism in CFI gene with AMD showed that there are no statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism (P˃0/05).

Conclusion: Our result show that p.Gly119Arg polymorphism of the CFI gene is unrelated to the susceptibility to AMD in Northwest of Iran.
کلیدواژه‌های انگلیسی مقاله AMD, polymorphism, CFI gene
نویسندگان مقاله ندا نوروزی | neda norouzi
tabriz university

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مرتضی بنیادی | mortaza bonyadi
tabriz of university


اسماعیل بابایی | esmaeil babaei
tabriz of university


محمد حسین جبارپور بنیادی | mohammad hossein jabbarpour bonyadi
ophthalmic research center shaheed beheshti university of medical sciences amp;amp; health services, tehran, iran
ophthalmologist, ophthalmic research center shaheed beheshti university of medical sciences amp;amp; health services, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

علیرضا جوادزاده | alireza javadzadeh
tabriz university of medical scinces

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://umj.umsu.ac.ir/browse.php?a_code=A-10-2602-1&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/27/article-27-416417.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده ژنتیک
نوع مقاله منتشر شده پژوهشی(توصیفی- تحلیلی)
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