Background & Aims: Air pollution has adverse effects on human health and cause various diseases including cardiovascular disease and respiratory. Therefore this study with aim of study of Number of total mortality, cardiovascular mortality and Chronic Obstructive Pulmonary Disease due to exposure with Nitrogen dioxide in Tehran during 2005-2014 were performed.

Materials & Methods: This study is a descriptive–analytic. At first hourly data were taken from Tehran environmental protection agency and Air Quality Control Company. Then validated according to the WHO guidelines and Statistical parameters for quantifying health effects were calculated in excel. Finally, assessment of cases total mortality with software was performed.

Results: The results showed that the number of total mortality caused by exposure to NO2 In the past decade is 15141 people. Also the total number of cardiovascular mortality in the past decade is 8480 people and the total number of Chronic Obstructive Pulmonary Disease in the past decade is 2454 people in 2005-2014 years.

Conclusion: Air pollution, especially nitrogen dioxide leads to mortality And Morbidity in a lot of people. According to the results of this study should such actions, policies and planning and management to reduce air pollution preparedness of hospitals and health centers, educating the public

Be done.