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Iranian Journal of Pediatric Hematology and Oncology، جلد ۷، شماره ۳، صفحات ۱۴۹-۱۵۳
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عنوان انگلیسی Evaluation of Immunoglobulin-A Level in Children with Acute Lymphoblastic Leukemia
چکیده انگلیسی مقاله Background: Acute lymphoblastic leukemia (ALL) is the most common type of leukemia among children. Immunoglobulin A is the most numerous immunoglobulin isotype in mucosal secretion. Immunoglobulin A (IgA) deficiency can increase risk of cancer in patients. Since few studies have been done on relation between serum IgA and ALL, this study was attempted to evaluate serum IgA in ALL patients. Materials and Methods: In this descriptive analytical study, 28 pediatric patients diagnosed with ALL with mean age of 6.75± 3.29 ranged from 1 to11 years old and 28 controls with mean age of 7.31± 4.12 ranged from 2 to 12 years old were chosen from Shahid Sadoughi Hospital. Serum IgA was measured by immunotorbidometric method (Pars Azmoon Kit, Iran). Pearson and Independent t test were used for the analysis of data. Results: In this study, the mean level of IgA was lower in patients with ALL (82.5± 21.3 mg/dl) in comparison to control group (113.2± 26.62 mg/dl). Moreover, there was significant difference between two groups (P< 0.01). Regarding patients age, no significant difference was seen either (P>0.05). Conclusion: According to the results of the present study, the serum level of IgA was significantly lower in ALL pediatric patients than the control group; however, it was in normal range in both groups. More studies are needed to strongly conclude IgA deficiency as a new risk factor or as a new marker of ALL in children. Other immunoglobulins are recommended to be considered in patients with ALL in further studies.
کلیدواژه‌های انگلیسی مقاله Acute Lymphoblastic Leukemia, Immonoglobulin, IgA deficiency
نویسندگان مقاله رباب شیخ پور | robab sheikhpour
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran


اعظم هاشمی | azam hashemi
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

الهام آخوندزاده | elham akhondzadeh
department of pediatric, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

z خنجرپناه | z khanjarpanah
department of pediatric, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

m میراخور | m mirakhor
department of pediatric, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

راضیه آخوندی | razieh akhondi
infectious research center, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-126&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/202/article-202-416432.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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