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Iranian Journal of Pediatric Hematology and Oncology، جلد ۷، شماره ۳، صفحات ۱۷۹-۱۹۱
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عنوان انگلیسی The Efficacy of Toll-Like Receptors in Awakening Dendritic Cell/Natural Killer Cell System for Eradication of Tumors
چکیده انگلیسی مقاله Natural killer (NK) cells are effector cells of the innate immune system that exert direct cytotoxic functions. Ubiquitously-expressed toll-like receptors (TLRs) have been recognized as one of the major components promoting dendritic cell (DC) maturation, which may induce polarized immune responses beneficial to cancer immunotherapy. TLR-activated NK cells and DCs are prerequisite for robust activation of the innate immune system against tumors. Recently, some medical research and clinical trials have proposed NK cells as a new therapy and potential strategy in both children and adults with those cancers which cannot be cured with the usual treatment modalities. As an example, the importance of DC/NK antitumor immunity in the outcome of breast and other cancers is recently recognized. Therefore, considering strategies which exploit TLR-mediated immunity in concordance with DC/NK system holds strong potential for cancer therapy. This review addresses the current knowledge about the potential role of TLR in tumor immunotherapy
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نویسندگان مقاله فاطمه پوررجب | fatemeh pourrajab
department of biochemistry and molecular biology, school of medicine, shahid sadoughi university of medical sciences, yazd, iran


پریسا i یزدانی elahabad | parisa i yazdani elahabad
school of medicine, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

سید حسین حکمتی مقدم | seyedhossein hekmatimoghaddam
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-130&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/202/article-202-416436.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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