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Iranian Journal of Pediatric Hematology and Oncology، جلد ۷، شماره ۳، صفحات ۱۹۲-۱۹۶

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عنوان انگلیسی Adrenocortical carcinoma in a 8 years old child: a Case Report
چکیده انگلیسی مقاله Background:Unilateral tumors or masses of the adrenal gland are common. They are categorized as either functional (hormone-secreting) or silent and as either benign or malignant. Adrenocortical tumors are rare in childhood, with an incidence of 0.3-0.5 cases per one million child-years. Almost half of childhood tumors are adrenocortical carcinomas (ACC). Most ACCs are sporadic, but specialy in children, some occur as a component of hereditary cancer syndromes. The most common presenting symptom occurring in 50-80% in children with ACC is virilization; overall, survival is poor for adrenocortical carcinoma (ACC). The prognosis in children who have adrenocortical carcinoma (ACC) appears to be better than that of adults, at least for early-stage disease. Residual or metastatic disease carries a poor prognosis. Complete resection is required for cure. Case presentation: The patient is a 8 years old girl presented progressive virilizing symptoms including deepening of the voice, clitoromegaly , growth acceleration, acne and premature pubic and axillary hair development before 8 years old. Conclusion: The clinical, biochemical, histological features along with differential diagnosis are discussed. This case is presented because of its rarity.This case study report a rare case and also to highlight the importance of differentiating ACC from an adenoma particularly in pediatric patients.
کلیدواژه‌های انگلیسی مقاله Adenoma, Adrenocortical Carcinoma, Child Virilization

نویسندگان مقاله فاطمه طباطبایی | fatemeh tabatabaei
. isfahan endocrine amp; metabolism research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمدرضا شریف | mohammad reza sharif
infectious disease research center, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

ناهید رییسی | nahid reisi
child growth amp; developmental research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)


نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-131&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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