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Physiology and Pharmacology، جلد ۲۱، شماره ۲، صفحات ۱۰۲-۱۰۹
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Treatment by Moringa oleifera extract can reduce gingival inflammatory cytokines in the rat periodontal model
چکیده انگلیسی مقاله Introduction: Overproduction of gingival pro-inflammatory cytokines have been implicated to play a noticeable role in the pathogenesis of periodontitis, which is characterized by host-mediated destruction of soft and hard periodontal tissues. Moringa oleifera (MO) is a highly valued medicinal plant which has a wide impressive range of traditional medical applications and is an alternative medicine for synthetic drugs which are accompanied with many downsides. The aim of this study was to investigate the effect of administration of the MO extract on gingival levels of TNF-α and IL1-β in the rat periodontal model. Methods: Inflammatory periodontitis was induced using 0-3 ligatures around the neck of right mandibular first molar in male rats. MO leaf extract was solved in dimethyl sulfoxide and injected into the gum tissue directly (500mg/kg) as a pre/post-treatment. Positive control group gave indomethacin (5mg/kg) on a daily basis. Gingival levels of TNF-α and IL1-β were measured using ELISA. Results: The results of this study revealed that levels of IL1-β and TNF-α increased in the gingival tissue in a model of periodontitis compared to control group (P≤0.001). Also, the results indicated that administration of MO extract could reduce production of TNF-α and IL1-β in the gum tissue of rat periodontal model (P≤0.001). There was no significant difference between MO extract and indomethacin anti-inflammatory effects. Conclusion: It can be concluded that pre/post-treatment with MO extract due to its direct effect on inhibition of pro-inflammatory cytokines can alleviate inflammatory symptoms in a rat periodontal model.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهدیه sahrakary | mahdiyeh sahrakary
dental faculty, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

ویدا ناظمیان | vida nazemian
neurophysiology research centre, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مریم آقالو | maryam aghaloo
dental faculty, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

اختر اکبری | akhtar akbari
functional neurosurgery research center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مهدی شادنوش | mahdi shadnoush
faculty of nutrition science and food technology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

بهزاد ناصری | behzad nasseri
department of physiology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

جلال زرین قلم | jalal zaringhalam
neurophysiology research centre, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-130-3&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-418781.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pain and addiction
نوع مقاله منتشر شده Short article (less than 3500 words)
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