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Iranian Journal of Microbiology، جلد ۹، شماره ۲، صفحات ۹۷-۱۰۲
عنوان فارسی
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عنوان انگلیسی Evaluating the relationship between serum immunoglobulin G (IgG) and A (IgA) anti-CagA antibody and the cagA gene in patients with dyspepsia
چکیده انگلیسی مقاله Background and Objectives: The cytotoxin-associated gene ( cag ) pathogenicity island is reported to be a major virulence factor of Helicobacter pylori infection. It is previously reported that the cagA -positive strains are more virulent, so it can be postulated that the cagA -positive gastritis will be more severe and the serum immunoglobulin G (IgG) and A (IgA) anti-CagA antibody titer will be higher. The aim of this study was to compare the relationship between IgG and IgA anti-CagA antibody and the cagA gene expression in patients with dyspepsia. Serum samples obtained from 130 dyspeptic patients with positive H. pylori in histological and Geimsa staining were tested for serum IgG and IgA anti-CagA antibody using the enzyme-linked immunosorbent Assay. The expression of the cagA gene was determined using PCR on the biopsy samples, taken via endoscopy. Results: In our material, the sensitivity of IgG anti-CagA antibody in identifying patients with a proven infection with the cagA -positive strains was 97.67%, and the negative likelihood ratios was 0.06. There was not significant correlation between serum IgA anti-CagA and the expression of the cagA gene among the dyspeptic patients. Conclusion: The IgG antibody titer was significantly higher in our patients with the cagA -positive H. pylori strain. However, in daily practice, the level of the IgG antibody titer cannot predict whether or not an individual carries a cagA -positive H. pylori strain, because there is a major overlap in the IgG antibody titer between the cagA -positive and cagA -negative patients.
کلیدواژه‌های انگلیسی مقاله cagA, IgG anti-CagA, IgA anti-CagA, Dyspepsia
نویسندگان مقاله هاشم فخر یاسری | hashem fakhre yaseri
gastroenterology, research center for gastroenterology and liver diseases, firoozgar hospital, iran university of medical sciences, tehran, iran and department of internal medicine, firoozgar hospital, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

علی برادران مقدم | ali baradaran moghaddam
department of microbiology, school of medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مهدی حسینی شکرابی | mehdi shekaraby
immunology research center, iran university of medical sciences, tehran, iran and department of immunology, school of medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

حمیدرضا | hamid reza baradaran
department of epidemiology, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سید کامران سلطانی عربشاهی | seyed kamran soltani arabshahi
department of internal medicine, firoozgar hospital, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/827
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/91/article-91-421317.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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