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Iranian Journal of Microbiology، جلد ۹، شماره ۲، صفحات ۱۱۲-۱۱۸
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran
چکیده انگلیسی مقاله Background and Objectives: Viruses have been suggested as one of the risk factors for psychiatric disorders. Among infectious agents Borna disease virus (BDV) has been known as a neurotropic virus which is able to cause neurological disorders in different animals. Recently there were controversial findings about BDV association with pathogenesis of human psychotic disorders. Materials and Methods: Here we performed a nested reverse transcription polymerase chain reaction for detection of BDV P40 RNA in peripheral blood mononuclear cell samples of schizophrenia (SC), bipolar disorder (BD) patients and healthy controls (HCs). Results: Only one out of 120 (0.8 %) psychiatric patients and two samples (2.7%) in 75 HCs showed positive results. There were no significant molecular evidence of BDV infection in 120 psychotic patients (60 SC and 60 BD) and 75 matched HCs. Conclusion: Our findings showed no association between BDV infection and pathogenesis of these psychiatric disorders. This is an interesting issue given both the as yet un-clarified role of BDV in human mental disorders and addressing patients in the so far under-investigating Middle East era.
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نویسندگان مقاله سمیه shatizadeh ملکشاهی | somayeh shatizadeh malekshahi
virology department, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حمید رضا احمدخانیها | hamid reza ahmadkhaniha
mental health research center, department of psychiatry, iran mental hospital, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سید جلال کیانی | seyed jalal kiani
virology department, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمد نجاتی | ahmad nejati
virology department, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

لیلا جنانی | leila janani
department of biostatistics, school of public health, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

ژیلا یاوریان | jila yavarian
virology department, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijm.tums.ac.ir/index.php/ijm/article/view/1161
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/91/article-91-421319.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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