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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۴، صفحات ۲۹۹-۳۰۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of fibrinolytic and antioxidant effects of Allium affine hydroalcoholic extract
چکیده انگلیسی مقاله Allium affine is a member of Amaryllidaceae family, which grows wildly in some western regions of Iran. Limited information is available about the pharmacological activities of this plant. The present study aimed to evaluate the fibrinolytic and antioxidant effects of hydroalcoholic extract of A. affine aerial parts. The in vitro antioxidant properties of the extract were evaluated by total phenolic content assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and ferric reducing antioxidant power (FRAP) assay. The in vivo studies included the determination of hydroperoxides level and FRAP value in serum samples of rats receiving i.p. injections of the plant extract for 21 days. The fibrinolytic activity of the extract was quantitatively evaluated by measuring the clot weight. In vitro antioxidant analysis exhibited the promising potential of DPPH scavenging and total antioxidant capacity of A. affine extract. In the in vivo analysis, A. affine extract reduced the serum hydroperoxides level and increased the serum total antioxidant capacity in rats. In vitro fibrinolytic assay also elucidated notable thrombolytic activity of the plant extract. The results of this study revealed the valuable antioxidant and in vitro fibrinolytic activities of A. affine extract. Further studies are needed for better evaluation of anticoagulant and thrombolytic activities of this plant and understanding its detailed mechanisms. 
کلیدواژه‌های انگلیسی مقاله Allium affine,Antioxidant,Fibrinolytic agents
نویسندگان مقاله مسعود صادقی | masoud sadeghi
1department of pharmacognosy and isfahan pharmaceutical sciences research center, school o


لیلا صفاییان | leila safaeian
2department of pharmacology and toxicology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمدرضا آقای قزوینی | mohammadreza aghaye ghazvini
3isfahan center of public health training and research, institute of public health research, tehran university of medical science, i.r. iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

مجتبی رمضانی | mojtaba ramezani
1department of pharmacognosy and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1773
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-421899.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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