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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۴، صفحات ۳۱۵-۳۲۱
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Atorvastatin attenuates ethanol-induced hepatotoxicity via antioxidant and anti-inflammatory mechanisms
چکیده انگلیسی مقاله The aim of this study was to evaluate the role of inflammation and oxidative damage in hepatotoxicity of ethanol. Also we assessed protective effects of atorvastatin against ethanol-induced hepatotoxicity. In this study, the animals were divided into five groups: control, ethanol (10 mg/kg intraperitoneal (i.p.)), ethanol with atorvastatin (10, 20 mg/kg/day, i.p.) and ethanol-vitamin C group which received ethanol (10 mg/kg/day) plus vitamin C (200 mg/kg, i.p.) for 28 consecutive days. Then, the animals were euthanized and liver tissues were separated. Biochemical markers ALT and AST were measured. Moreover, glutathione (GSH) content, lipid peroxidation, protein carbonyl, nitric oxide and tumor necrosis factor-α (TNF-α) were evaluated. The administration of ethanol for 28 days resulted in an increase in liver damage, oxidative stress and inflammatory markers. The atorvastatin was able to prevent the ethanol-induced hepatotoxicity by decreasing the oxidative stress and inflammation processes. Our study showed the critical role of oxidative damage and inflammation in ethanol-induced hepatotoxicity that markedly was inhibited by administration of atorvastatin. Therefore, atorvastatin can be suggested for prevention of ethanol-induced hepatotoxicity.
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نویسندگان مقاله احسان زمانی | ehsan zamani
1pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran. 2student research committee, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

مهتاب محمدباقری | mahtab mohammadbagheri
3department of pharmacology and toxicology, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

مرجان فلاح | marjan fallah
3department of pharmacology and toxicology, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

فاطمه شکی | fatemeh shaki
1pharmaceutical sciences research center, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran. 3department of pharmacology and toxicology, faculty of pharmacy, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1775
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-421901.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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