این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Toxicology، جلد ۱۱، شماره ۵، صفحات ۵-۱۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله خردل گوگردی، استرس اکسیداتیو، شدت بیماری، خلط
عنوان انگلیسی The Role of Oxidative Stress in Severity of Obstructive Pulmonary Complications in Sputum of Sulfur Mustard-Injured Patients
چکیده انگلیسی مقاله Background: Sulfur mustard (SM) is a strong bifunctional alkylating agent that causes delayed complications in organs such as lung. Oxidative stress plays a pivotal role in the pathogenesis and progression of many pulmonary diseases. The aim of this study was to investigate the oxidative stress in sputum of SM exposed patients with mild, moderate and severe pulmonary dysfunction and assessing their relationship with pulmonary function. Methods: In this cross–sectional study, oxidative stress biomarkers in sputum were examined on 26 patients with SM-induced bronchiolitis obliterans (9 mild, 14 moderate and 3 severe) and 12 matched healthy controls referred to Baqiyatallah Hospital, Tehran between October 2015 and April 2016. Results: Sputum superoxide dismutase, catalase and glutathione S-transferase activities and malondialdehyde level in moderate and severe groups were significantly higher than in the control group (P=0.002, P=0.004, P=0.014 and P=0.009, respectively). Glutathione (GSH) level in moderate (22.29%, P=0.025) and severe (45.07%, P=0.004) groups were significantly lower than the control. A decreased in GSH level in severe (41.7%) groups was observed as compared with the mild group. Pearson analysis revealed strong correlations between disease severity and oxidative stress biomarkers in sputum of patients with moderate and severe injuries. Conclusions: Oxidative stress is involved in the pathogenesis of patients with moderate and severe pulmonary dysfunction following SM exposure. The presence of enhanced oxidative stress relates to the decline lung function and the progression of the disease. Sputum induction in SM-injured patients can be used to the assessment of the antioxidant status of bronchial secretions.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله جواد حیدری | javad heydari
department of biochemistry, faculty of medicine, baqiyatallah university of medical sciences, tehran, iran.
تهران، میدان ونک، خیابان ملاصدرا
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

مهوش جعفری | mahvash jafari
department of biochemistry, faculty of medicine, baqiyatallah university of medical sciences, tehran, iran.
تهران، میدان ونک، خیابان ملاصدرا
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

سعید خزایی | saeed khazaie
department of biochemistry, faculty of medicine, baqiyatallah university of medical sciences, tehran, iran.
تهران، میدان ونک، خیابان ملاصدرا
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

حسن گوشه | hassan goosheh
md, pulmonologist, chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran.
تهران، میدان ونک، خیابان ملاصدرا
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

مصطفی قانعی | mostafa ghanei
md, pulmonologist, chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran.
تهران، میدان ونک، خیابان ملاصدرا
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

اشرف کرباسی | ashraf karbasi
md, pulmonologist, chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran.
تهران، میدان ونک، خیابان ملاصدرا
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-448-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/138/article-138-423015.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات