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Journal of Dentomaxillofacil Radiology, Pathology and Surgery، جلد ۶، شماره ۱، صفحات ۱-۷
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چکیده فارسی مقاله
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عنوان انگلیسی The Effect of Oral Curcumin on Pain and Clinical Appearance of Oral Lichen Planus
چکیده انگلیسی مقاله Introduction: Lichen planus is an inflammatory mucocutaneous disease that its etiology is still unknown. Various treatments are used to mitigate the pain, inflammation, and duration of lesions. Due to the lack of a definitive treatment and the side effects of current treatments, many efforts still have been making to find new treatments. As curcumin has been shown to have anti-inflammatory, analgesic, antimicrobial, and anti-tumor properties, this study was designed to study the effect of oral curcumin in treating oral lichen planus. Materials and methods: Ten patients with oral atrophic, erosive lichen planus participated in a pilot clinical trial intervention study. The patients were treated with 3 strips of Sina Curcumin capsules 80 mg, one capsule every day after breakfast for 4 weeks. The clinical appearance of lesions (based on the Thongprasom score) and pain severity (based on the Visual Analogue Score) were recorded before treatment and at the end of the first, second, and fourth weeks of the intervention. Results: Using repeated measures analyses of variance, there were statistically significant differences in pain intensity (P = 0.043) and clinical appearance of oral lesions (P = 0.001) in patients treated with curcumin before and after treatment. At the end of the treatment period, pain was reduced in 50% of the patients and full recovery was observed in 20% of the patients. Clinical appearance of oral lesions indicated recovery in 20% of the patients. Conclusion: Using a nanomicell formulation of oral curcumin could be considered as an alternative treatment for oral lichen planus. This drug is safe and has few side effects. However, it needs further studies with larger sample sizes and follow up periods.
کلیدواژه‌های انگلیسی مقاله Aphthous , Curcumin, Triamcinolone Acetonide, Therapeutics.
نویسندگان مقاله سید جواد کیا | seyed javad kia
dental sciences research center,department of oral and maxillofacial medicine


مریم بصیرت | maryam basirat
dental sciences research center,department of oral and maxillofacial medicine


لیلا استخر | leila estakhr
guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

نشانی اینترنتی http://3dj.gums.ac.ir/browse.php?a_code=A-10-1-120&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/260/article-260-423178.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده So on
نوع مقاله منتشر شده پژوهشی
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