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Iranian Journal of Public Health، جلد ۴۶، شماره ۹، صفحات ۱۲۸۵-۱۲۹۱
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عنوان انگلیسی The Prevalence of Plasmid-mediated Quinolone Resistance Genes in Escherichia coli Isolated from Hospital Wastewater Sources in Tehran, Iran
چکیده انگلیسی مقاله Abstract Background: Considering the importance of hospital wastewaters as potential reservoirs for the dissemination of bacterial pathogens such as Escherichia coli and antibiotic resistance genes in the environment, the need for such information becomes imperative. Methods: E. coli strains were isolated from hospital wastewater sources in Tehran, Iran, over a 24-month sampling period (Jun 2014- Jun 2016) and identified using standard bacteriological methods. Quinolone resistance among the strains was determined using Kirby-Bauer method and the frequency of plasmid-mediated quinolone resistance genes ( qnrA , qnrB , qnrS ) was investigated by PCR. Results: In total, 80 E. coli strains were isolated during the study period, of which 51 (63.8%) isolates were resistant to tested antibiotics. Of note, 13 isolates were resistant to all the antibiotics employed. The highest rates of antibiotic resistance were obtained for nalidixic acid (60%), followed by norfloxacin (30%), and ciprofloxacin (25%). Of the 51 quinolone-resistant strains, 24 (47.1%) isolates harbored qnr genes. None of the isolates harboured the qnrA gene, while 11 (45.8%) and 7 (29.2%) isolates contained qnrB and qnrS , respectively. Conclusion: Our findings showed high rates of quinolone resistance (63.8%) and qnr genes, underlining the importance of hospital wastewaters as reservoirs for dissemination of potentially pathogenic E. coli and horizontal gene transfer between other waterborne bacterial species. Other possible mechanisms of resistance should also be investigated for better characterization of quinolone-resistant E. coli isolates.
کلیدواژه‌های انگلیسی مقاله Escherichia coli, Quinolone, Hospital wastewater, Iran
نویسندگان مقاله رضا رنجبر | reza ranjbar
molecular biology research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

امید فراهانی | omid farahani
dept. of microbiology, islamic azad university, varamin-pishva branch, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/11002
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-426974.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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