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Iranian Journal of Public Health، جلد ۴۵، شماره ۱۰، صفحات ۱۳۲۲-۱۳۳۱
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عنوان انگلیسی Can Opium Use Contribute to a Higher Risk of Colorectal Cancers? A Matched Case-control Study in Iran
چکیده انگلیسی مقاله Background: Colorectal cancers (CRCs) including colon, rectum and anal cancers are the third most prevalent cancers in the world. There are strong evidence showing the risk of the cigarette smoking, alcohol use, low physical activity and some types of diets in CRCs; however, few studies explored the relationship between opium use and CRCs. This study aimed to investigate the association between opioid use and the incidence of CRCs. Methods: In a population-based matched case-control study in Kerman, Iran, 175 patients with colorectal cancers and 350 healthy controls (matched for age, sex, and place of residence) were interviewed from Sep 2014 to Nov 2014. Opium and its derivatives, cigarette, alcohol, and diet use were collected using a valid and reliable questionnaire. Conditional logistic regression was used to estimate odds ratios with 95% confidence intervals. Results: The use of opioids was associated with an increased risk of CRCs (adjusted odds ratio= 4. 5, 95% CI: 2. 4-8. 7). In addition, a dose-response relationship was observed between the cumulative use of opioids and the incidence of CRCs (with low use OR=3. 7; 95% CI: 1. 5-8. 6 and high use OR= 8. 0; 95% CI: 2. 9-21. 7). This dose-response relationship was also strong in patients with colon cancers, with OR= 3. 9 (95% CI: 1. 5-9. 9) and 9. 4 (95% CI: 3. 3-27. 0) for the low and high uses of opioids, respectively. Conclusion: Opioid use can lead to an increased risk of CRCs. Therefore, it is necessary to implement preventive policies to control the use of opioids.
کلیدواژه‌های انگلیسی مقاله Risk factor, Colorectal cancers, Opioid, Case-control, Iran
نویسندگان مقاله احمد نقیب زاده تهامی | ahmad naghibzadeh tahami


وحید یزدی فیض آبادی | vahid yazdi feyzabadi


نرگس خانجانی | narges khanjani


احد اشرفی عسگرآباد | ahad ashrafi asgarabad


حسنیه alizaeh | hosniyeh alizaeh


وحید رضا برهانی نژاد | vahid reza borhaninejad


محمد مرادی joo | mohammad moradi joo


مسعود زینالی | masoud zeinali


محمد جواد زاهدی | mohammad javad zahedi


محمود آقایی افشار | mahmoud aghaee afshar


علی اکبر حقدوست | ali akbar haghdoost


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/8071
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زبان مقاله منتشر شده en
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