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Iranian Journal of Public Health، جلد ۴۵، شماره ۷، صفحات ۹۳۵-۹۴۰
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عنوان انگلیسی No Evidence of Human Herpesvirus 8 among Iranian Patients Infected with HIV
چکیده انگلیسی مقاله Background: Kaposi’s sarcoma is a vascular malignancy, which frequently occurs among immunocompromised individuals such as transplant recipients and patients with acquired immunodeficiency syndrome. Human herpesvirus 8 (HHV-8) is considered the etiological agent of all forms of Kaposi’s sarcoma. Though some seroepidemiological studies conducted on the prevalence of HHV-8 in Iran, there are insufficient data on the prevalence of HHV-8 viremia in HIV infected patients. We therefore, aimed to determine the prevalence of HHV-8 viremia in general population and HIV infected patients without Kaposi’s sarcoma in Tehran, Iran. Methods: We conducted a cross sectional survey on 99 patients with HIV infection referred to Iranian Research Center for HIV/AIDS and 40 healthy controls in Tehran, Iran from January to April 2014. The presence of HHV-8 DNA was detected in buffy coat samples of enrolled subjects using nested PCR assay. Results: A total of 99 HIV infected patients with mean age of 37.9±10 yr and 40 healthy controls with mean age of 39±11.5 yr were enrolled in the study. The mean CD4 count was 410.3± 211.4 cells/mm 3 . HHV-8 DNA was not detected in both healthy control and HIV patient groups. Conclusion: This survey showed low rate of HHV-8 DNA in healthy controls and HIV patients. Considering our findings HHV-8 infection does not seem to be widespread in our population. Further studies focusing on different regions of Iran appear to be required to have a more accurate estimation.
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نویسندگان مقاله آمیتیس رمضانی | amitis ramezani


الهام صبوری | elham saboori


کیهان آزادمنش | kayhan azadmanesh


مینو محرز | minoo mohraz


منیره کاظمی منش | monireh kazemimanesh


افسانه کرمی | afsaneh karami


محمد بنی فضل | mohammad banifazl


هانیه گلچهرگان | hanieh golchehregan


آرزو آقاخانی | arezoo aghakhani


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/7327
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