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Acta Medica Iranica، جلد ۵۵، شماره ۱، صفحات ۲۹-۳۴
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عنوان انگلیسی The Possible Role of Nitric Oxide and Oxidative Stress in the Enhanced Apoptosis of Cardiac Cells in Cirrhotic Rats
چکیده انگلیسی مقاله  Cirrhosis has been related with hyperdynamic circulation, manifesting as increased cardiac output and decreased systemic vascular resistance. In the present study we examined the cirrhosis outcome on apoptosis of rat hearts. We also tried to explore the role of nitric oxide (NO) and oxidative stress in the probable changed apoptosis of cirrhotic hearts. Twenty eight days after ligation of bile duct, heart tissues were tested for apoptosis. The extent of malondialdehyde (MDA), and the activities of catalase (CAT), glutathione peroxidase (GSHPx) and superoxide dismutase (SOD) have been calculated in heart tissues. The cirrhotic hearts exhibited structural defects and greater apoptosis. Chronic treatment of cirrhotic rats with L-NAME, a non-selective inhibitor of NO synthase, inhibited heart structural defects and reduced apoptosis of hearts. We also showed that cirrhotic rat hearts had an enhanced level of MDA and reduced activities of CAT, GSHPx and SOD. When the animals were treated by L-NAME chronically, the MDA level reduced and activities of CAT, GSHPx and SOD augmented in cirrhotic heart. In conclusion, increased apoptosis of cirrhotic hearts probably happen due to NO overproduction and increased oxidative stress in hearts of cirrhotic rats.
کلیدواژه‌های انگلیسی مقاله Cirrhosis,Heart,Apoptosis,Nitric oxide,Oxidative stress
نویسندگان مقاله حامد شفارودی | hamed shafaroodi
department of molecular genetics, tehran medical branch, islamic azad university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهرداد هاشمی | mehrdad hashemi
department of anatomy, tehran medical branch, islamic azad university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

زهرا نادیا شریف | zahra nadia sharif
department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran. and pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

لیلا معزی | leila moezi
department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran. and the persian gulf marine biotechnology research center, bushehr university of medical sciences, bushehr, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)

زینب جان احمدی | zeinab janahmadi
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احمدرضا دهپور | ahmad reza dehpour


نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5329
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-430349.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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