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Iranian Journal of Public Health، جلد ۴۴، شماره ۶، صفحات ۸۱۴-۸۲۱
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عنوان انگلیسی Combination Effect of GSTM1, GSTT1 and GSTP1 Polymorphisms and Risk of Systemic Lupus Erythematosus
چکیده انگلیسی مقاله Background : Progression of systemic lupus erythematosus (SLE) could be due to oxidative stress especially through reactive oxygen species (ROS). Detoxification of ROS is largely performed by Glutathione S-transferases (GSTs), therefore polymorphisms of GSTM1, GSTT1 and GSTP1 genes which decrease enzymes activity could affect SLE susceptibility. The aim of this study was to determine the effects of GSTM1 (deletion), GSTT1 (deletion) and GSTP1 (Ile105Val) polymorphisms on SLE susceptibility. Methods : Genomic DNA was extracted from blood samples of 163 SLE patients and 180 age, sex and ethnically matched controls. GSTs genotypes were determined by polymerase chain reaction (PCR)-multiplex procedure or pol-ymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results : GSTT1 null genotype frequency was higher in SLE patients than controls. NO association observed between GSTM1 null genotype or GSTP1 Ile105Val polymorphism with SLE. Nevertheless combination of GSTT1 null/ GSTM1 null genotypes showed 2.8-fold increase in risk of SLE. Moreover the combination of GSTT1 null/ GSTM1 null/GSTP1 Ile/Val and Val/Val genotypes increased the SLE risk about 8 fold. Conclusion : Present data suggest that GSTT1 null/ GSTM1 null/GSTP1 Ile/Val and Val/Val genotypes might large-ly contribute to the pathogenesis of SLE.
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نویسندگان مقاله سعیده سلیمی | saeedeh salimi
cellular and molecular research center, zahedan university of medical sciences, zahedan, iran and dept. of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

علیرضا نخعی | alireza nakhaee
cellular and molecular research center, zahedan university of medical sciences, zahedan, iran and dept. of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

مهدی جعفری | mehdi jafari
cellular and molecular research center, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

دانیال جهانتیغ | danial jahantigh
dept. of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

مهناز صندوقی | mahnaz sandooghi
dept. of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

زهرا ذاکری | zahra zakeri
dept. of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

مهناز شهرکی پور | mahnaz shahrakipour
dept. of biostatistics and epidemiology, school of public health, zahedan university of medical sciences; zahedan, iran and pregnancy health research center, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

انوش نقوی | anoosh naghavi
cellular and molecular research center, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

فرزانه فرجیان مشهدی | farzaneh farajian mashhadi
cellular and molecular research center, zahedan university of medical sciences, zahedan, iran and dept. of pharmacology, school of medicine, zahedan university of medical sciences, zahedan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/3302
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