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Iranian Journal of Public Health، جلد ۴۳، شماره ۱۲، صفحات ۱۶۵۱-۶
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عنوان انگلیسی The Effects of Vitamin D Supplementation on Glucose Control and Insulin Resistance in Patients with Diabetes Type 2: A Randomized Clinical Trial Study.
چکیده انگلیسی مقاله Vitamin D deficiency is prevalent in diabetes type 2 and this vitamin may be related to insulin action. This randomized controlled trial study was done to evaluate the effect of vitamin D supplementation on glucose control and insulin resistance in patients with diabetes type 2.Participants of this randomized clinical trial study consisted of 28 patients with type 2 diabetes who received 100 microgram (4000 IU) vitamin D and 30 diabetic patients who received placebo for 2 months between September 2012 and February 2013. The effect of vitamin D on glucose control was assessed by measuring HbA1c and insulin resistance as HOMA-IR at the baseline and the end of the intervention.The results showed a significant decrease in HbA1c (from 7.29 ± 0.22 % to 6.76 ± 0.18 %, P< 0.001) and insulin concentration (from 8.24 ± 0.97 μIU/mL to 6.55 ± 0.28 μIU/mL, P=0.048), but a non-significant decrease in HOMA-IR in vitamin D group. Also, HDL-C level increased significantly in both of vitamin D (P=0.046) and placebo groups (P=0.028).It seems that vitamin D supplementation has beneficial effects on glucose homeostasis and can increases insulin sensitivity in diabetic 2 patients.
کلیدواژه‌های انگلیسی مقاله Diabetes type 2,HbA1c,Insulin resistance,Vitamin D
نویسندگان مقاله اسماعیل یوسفی راد | esmaeil yousefi rad
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمود جلالی | mahmoud djalali
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فریبا کوهدانی | fariba koohdani
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی اکبر صبور یراقی | ali akbar saboor yaraghi
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد رضا اشراقیان | mohammad reza eshraghian
dept. of biostatistics, school of public health, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد حسن جوانبخت | mohammad hassan javanbakht
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سمیه صبوری | somayeh saboori
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهناز زارعی | mahnaz zarei
dept. of cellular and molecular nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد جواد حسین زاده عطار | mohammad javad hosseinzadeh attar
dept. of clinical nutrition, school of nutritional sciences and dietetics, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/3760
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