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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۵، صفحات ۳۹۱-۴۰۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The protective effect of sodium benzoate on aluminum toxicity in PC12 cell line
چکیده انگلیسی مقاله Sodium benzoate (SB) is one of the food additives and preservatives that prevent the growth of fungi and bacteria. SB has been shown to improve the symptoms of neurodegenerative disease such as Alzheimer’s disease. The aim of this study was to evaluate the effect of SB on the cell survival and cellular antioxidant indices after exposure to aluminum maltolate (Almal) in PC12 cell line as a model of neurotoxicity. The cells exposed to different concentrations of SB (0.125 to 3 mg/mL) in the presence of Almal (500 µM) and cell viability, the level of reactive oxygen species (ROS), glutathione content and catalase activity were measured. The results showed that low concentrations of SB caused an increase in the cell survival, but cell viability was reduced in high concentrations. SB could neither prevent the level of ROS production nor change glutathione content. SB (0.5 mg/mL) significantly increased the catalase enzyme activity as compared to the Almal. This study suggested that SB did not completely protect the cell to aluminum-induced free radicals toxicity. Possibly SB improves the symptoms of neurodegenerative disease by other mechanisms.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله ریتا عرب سلغار | rita arabsolghar
2department of medical biotechnology, school of advanced medical sciences and technology, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

جمیله صابرزاده | jamileh saberzadeh
3department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

فروزان خدایی | forouzan khodaei
3department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

روژین عباسی بروجنی | rozhin abbasi borojeni
4department of biochemistry, school of paramedical sciences, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مرجان خورسند | marjan khorsand
3department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مرضیه راشدی نیا | marzieh rashedinia


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1785
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-432187.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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