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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۵، صفحات ۴۰۱-۴۰۸
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عنوان انگلیسی Can allopurinol improve retinopathy in diabetic rats? Oxidative stress or uric acid; which one is the culprit?
چکیده انگلیسی مقاله Allopurinol, an inhibitor of xanthine oxidase, reduces both plasma uric acid and oxidative stress and shows useful effects on some complications of diabetes. However, it is not defined which of the above mentioned properties are involved. Moreover, to the best of our knowledge no study has been done on the effects of allopurinol on diabetic retinopathy. In the present study, the effect of allopurinol on experimental diabetic retinopathy and its possible mechanism has been investigated. Thirty two rats were divided into four groups of eight rats each; (1) normal, (2) diabetic control, (3) diabetic + allopurinol (50 mg/kg.day), (4) diabetic + benzbromarone (10 mg/kg.day). Drugs were administered daily and orally from the day after diabetes induction for eight weeks. Thereafter retinal function and structure were evaluated by electroretinography and microscopic studies. Uric acid and oxidative stress biomarkers were measured biochemically. Diabetes significantly increased plasma uric acid and oxidative stress markers and reduced body weight and amplitude of electroretinogram (ERG) b-wave and oscillatory potentials. Treatment of diabetic rats with allopurinol caused a significant increase in the amplitude of ERG b-wave (87%) and decrease in blood sugar (20%), uric acid (49%), and 8-iso-prostaglandin F2α (56%), but had no effect on the number of retinal ganglionic cells and oscillatory potentials. Benzbromarone showed no significant effects on the considered parameters except the reduction of uric acid. Allopurinol improved the b-wave amplitude of diabetic rats. It seems that this beneficial effect is due to the reduction of oxidative stress rather than its effect on plasma uric acid.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محسن گوهری نیا | mohsen goharinia
2department of ophthalmology, faculty of medicine, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

اطهر زارعی | athar zareei
2department of ophthalmology, faculty of medicine, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

منصور رحیمی | mansour rahimi
1department of pharmacology, faculty of medicine, shiraz university of medical sciences, shiraz, i.r. iran. 3medicinal and natural products chemistry research center, shiraz university of medical sciences, shiraz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

حسین میرخانی | hossein mirkhani


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1786
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-432188.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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