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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۵، صفحات ۴۱۶-۴۲۴
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عنوان انگلیسی Effects of hydroalcoholic extract of Rhus coriaria seed on glucose and insulin related biomarkers, lipid profile, and hepatic enzymes in nicotinamide-streptozotocin-induced type II diabetic male mice
چکیده انگلیسی مقاله Type 2 diabetes often leads to dislipidemia and abnormal activity of hepatic enzymes. The purpose of this study was to evaluate the antidiabetic and hypolipidemic properties of Rhus coriaria ( R. coriaria ) seed extrac on nicotinamide-streptozotocin induced type 2 diabetic mice. In this experimental study, 56 male Naval Medical Research Institute mice (30-35 g) were randomly separated into seven groups: control, diabetic group, diabetic mice treated with glibenclamide (0.25 mg/kg, as standard antidiabetic drug) or R . coriaria seed extract in doses of 200 and 300 mg/kg, and control groups received these two doses of extract orally for 28 days. Induction of diabetes was done by intraperitoneal injection of nicotinamide and streptozotocin. Ultimately, body weight of mice, blood levels of glucose, insulin, hepatic enzymes, leptin, and lipid profile were assayed. After induction of type 2 diabetes, level of glucose, cholesterol, low density lipoprotein, serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase increased and level of insulin and high density lipoprotein decreased remarkably. Administration of both doses of extract decreased level of glucose and cholesterol significantly in diabetic mice. LDL level decreased in treated group with dose of 300 mg/kg of the extract. Although usage of the extract improved level of other lipid profiles, insulin and hepatic enzymes, changes weren’t significant. This study showed R. coriaria seeds administration has a favorable effect in controlling some blood parameters in type 2 diabetes. Therefore it may be beneficial in the treatment of diabetes.
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نویسندگان مقاله اکرم آهنگرپور | akram ahangarpour
1health research institute, diabetes research center, department of physiology, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran. 2cellular and molecular research center, qom university of medical sciences, qom, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

حمید حیدری | hamid heidari
3student research committee, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

مجید salehizade junghani | majid salehizade junghani
3student research committee, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

رضا absari | reza absari
3student research committee, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

مهدی خوگر | mehdi khoogar
3student research committee, ahvaz jundishapur university of medical sciences, ahvaz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

احسان قایدی | ehsan ghaedi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1788
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-432198.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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