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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۵، صفحات ۴۲۵-۴۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Docking study, synthesis and antimicrobial evaluation of some novel 4-anilinoquinazoline derivatives
چکیده انگلیسی مقاله A series of novel 4-anilinoquinazoline derivatives were designed and synthesized from benzoic acid through ring closure, chlorination or nucleophilic substitution. The structures of compounds were characterized by IR, 1 H-NMR and mass spectroscopy. All synthesized derivatives were screened for their antimicrobial activities against Gram-positive (Staphylococcus aurous, Bacillus subtilis, Listeria monocitogenes) and Gram-negative (Escherichia coli , Pseudomonas aeruginosa , Salmonella entritidis ) bacteria and also for antifungal activities against Candida albicans using the conventional micro dilution method. Most of the compounds have shown good antibacterial activities, especially compound 4c having highest activities against E. coli at 32 μg/mL concentration while the tested compounds did not exhibited remarkable antifungal activities. The potential DNA gyrase inhibitory activity of these compounds was investigated in silico using molecular docking simulation method. All compounds showed good results especially compound 4c which showed the lowest ∆G bind results (-8.16 Kcal/mol).
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله رضوان رضایی نسب | rezvan rezaee nasab
1department of medicinal chemistry and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

فرشید حسن زاده | farshid hassanzadeh
1department of medicinal chemistry and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

قدمعلی خدارحمی | ghadam ali khodarahmi
1department of medicinal chemistry and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محبوبه رستمی | mahboubeh rostami
1department of medicinal chemistry and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمود میرزایی | mahmoud mirzaei
2department of pharmaceutical biotechnology and isfahan pharmaceutical sciences research center, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی جهانیان نجف آبادی | ali jahanian najafabadi
3medicinal plants research center, yasuj university of medical sciences, yasuj, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

محبوبه منصوریان | mahboubeh mansourian


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1789
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-432199.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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