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Research in Pharmaceutical Sciences، جلد ۱۱، شماره ۶، صفحات ۴۳۵-۴۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Dramatic improvement in dissolution rate of albendazole by a simple, one-step, industrially scalable technique
چکیده انگلیسی مقاله Low solubility and dissolution rate are the primary challenges in the drug development which substantially impact the oral absorption and bioavailability of drugs. Due to the poor water solubility, Albendazole (ABZ) is poorly absorbed from the gastrointestinal tract and shows low oral bioavailability (5%) which is a major disadvantage for the systemic use of ABZ. To improve the solubility and dissolution rate of ABZ, different classes of hydrophilic excipients such as sugars (lactose, sucrose, and glucose), polyols (mannitol and sorbitol), ionic surfactant (sodium lauryl sulfate) and non-ionic surfactant (Cremophor A25) were co-spray dried with ABZ. The crystallinity changes in the processed drug were characterized by differential scanning calorimetry and X-Ray diffraction methods were used to interpret the enhanced solubility and dissolution rate of the drug. Results showed that the solubility and dissolution rate of ABZ were increased 1.8-2.6 folds and 3-25 folds, respectively. Unexpectedly, SLS decreased the solubility index of drug powder even lower than the unprocessed drug which was attributed to drug-SLS ionic interaction as depicted from Fourier transform infrared spectroscopy. It was concluded that by applying the facile, one-step, industrially scalable technique and the use of small amounts of excipient (only 4% of the formulation), a great improvement (21 folds) in dissolution rate of ABZ was achieved. This finding may be used in the pharmaceutical industries for the formulation of therapeutically efficient dosage forms of class II and IV drugs classified in biopharmaceutical classification system.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سعید قنبرزاده | saeed ghanbarzadeh
2biotechnology research center and faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

آرام خلیلی | aram khalili
3drug applied research center, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

ابوالقاسم جویبان | abolghasem jouyban
4research center for pharmaceutical nanotechnology and students’ research committee, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

شهرام امامی | shahram emami
2biotechnology research center and faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

یوسف جوادزاده | yousef javadzadeh
5department of research and development, zahravi pharmaceutical company, tabriz, i.r. iran.


محمد صلحی | mohammad solhi
3drug applied research center, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

حامد همیشه کار همیشه کار | hamed hamishehkar hamishehkar


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1724
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-432221.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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