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Research in Pharmaceutical Sciences، جلد ۱۱، شماره ۶، صفحات ۴۵۴-۴۶۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms
چکیده انگلیسی مقاله The present study was designed to study the preventive effect of hydroalcoholic extract of ripe pistachio hulls (RPH) in the elevated plus maze model of anxiety. One hundred twenty female wistar rats in their estrous cycle were divided into 15 groups of 8 each and received various concentrations of hydroalcoholic extract of RPH except the control groups. Elevated plus maze was used to measure the level of anxiety. Percentage of time spent in the open arms (%OAT), percentage of the number of entries into the open arms (%OAE), locomotor activity, and time spent in the closed arms (CAT), and the number of entries in to the closed arms (CAE) were measured and compared. Dose-response experiments showed that only 10 mg/kg dose of RPH extract significantly increased %OAT ( P < 0.001) and %OAE ( P < 0.05) compared to the control group, indicating anti-anxiety effects of the extract. Also, pentylenetetrazol and an estrogen receptor antagonist (ERA) tamoxifen could block anti-anxiety effects of the extract ( P < 0.001). It was also noticed that tamoxifen was able to significantly reduce locomotor activity. As the RPH extract showed a preventive effect in experimental model of anxiety, it might be concomitantly administered with other anxiolytic medications.
کلیدواژه‌های انگلیسی مقاله Anxiety,Ripe pistachio hulls,PTZ,Estrogen,Plus maze
نویسندگان مقاله محمد رستم پور | mohammad rostampour
3department of biology, faculty of science, kharazmy university. tehran, i.r. iran


الهام هادی پور | elham hadipour
3department of biology, faculty of science, kharazmy university. tehran, i.r. iran


شهربانو عریان | shahrbano oryan
4department of pharmacology, guilan university of medical sciences, rasht, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

بهرام سلطانی | bahram soltani
1cellular and molecular research center, guilan university of medical sciences, rasht, i.r. iran. 5department of immunology, guilan university of medical sciences, rasht, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

فرشید سعادت | farshid saadat


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1726
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-432223.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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