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Research Journal of Pharmacognosy، جلد ۴، شماره ۴، صفحات ۷-۱۵
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عنوان انگلیسی In vivo analgesic and anti-inflammatory effects of the essential oil from Artemisia sieberi fruit
چکیده انگلیسی مقاله Background and objectives: Drugs with analgesic properties such as opioids and NSAIDs have not been effective in all cases, because of their low potency and side effects. As a result, looking for other alternatives is necessary. Plants are important sources of new phytochemicals that possess significant therapeutic effects. Regarding the traditional use of Artemisia sieberi fruit as a natural painkiller and anti-inflammatory agent and the high content of essential oil in the fruits, we were prompted to investigate the anti-inflammatory and analgesic activities of A. sieberi fruits oil. Methods: Artemisia sieberi fruits essential oil was extracted by hydrodistillation method. The analgesic and anti-inflammatory activities of the oil were studied by formalin and carrageenan tests, respectively at the doses of 0.2, 0.4 and 0.8 mg/kg for the experimental animals. Control group received sweet almond oil as the vehicle and standard groups received morphine (2 mg/kg) and indomethacin (5 mg/kg) for the formalin and carrageenan tests respectively. Results: All doses of A. sieberi fruits essential oil induced antinociceptive activity during the second phase of the formalin test but the maximum effect was observed at the dose of 0.8 mg/kg. In carrageenan test all the experimental doses of theoil significantly reduced the inflammation (p< 0.05). Anti-inflammatory activity of A. sieberi oil (0.2, 0.4 and 0.8 mg/kg) was found to be as considerable as the standard drug indomethacin (5 mg/kg). Conclusion: Artemisia sieberi fruit essential oil showed analgesic and anti-inflammatory effects which might be attributed to the major components of the studied oil, camphor and 1,8-cineole.  
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نویسندگان مقاله a دارابیان |
herbal medicines research center, pharmaceutical sciences branch, islamic azad university, tehran, iran hmrc .
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

z موسوی |
department of pharmacology and toxicology, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, iran iaups .
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

j عسگرپناه |
department of pharmacognosy, faculty of pharmacy, pharmaceutical sciences branch, islamic azad university, tehran, iran iaups .
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

a بختیاریان |
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://www.rjpharmacognosy.ir/article_50339_783d507cf723ce715ad4da93ac9f742a.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/338/article-338-432411.pdf
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