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Molecular Biology Research Communications، جلد ۶، شماره ۳، صفحات ۱۱۳-۱۲۲
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عنوان انگلیسی Assessment of vocation of rifabutin and rifapentine in replace of rifampcin in drug resistance leprosy patients: a molecular simulation study
چکیده انگلیسی مقاله The emergence of drug resistance in leprosy is a major hurdle in leprosy elimination programme. Although the problem of drug resistance is presently not acute, it is important that we collect data more systematically and monitor the trend carefully so that effective measures to combat this problem can be developed. The present study aimed at the explication of cross resistance of rifabutin and rifapentine to rifampicin which would be helpful to programme managers for implementing rifabutin or rifapentine in replace of rifampicin. In this study we built 3D model of the M. leprae rpoB using Swiss Model and the modelled structure was docked with rifampicin, rifabutin and rifapentine. We established that these 3 antibiotics interact with the same binding region in the modelled rpoB of M. leprae. Thus we conclude that vocation of rifabutin and rifapentine could not be suitable in replace of rifampicin to combat with drug resistance leprosy.
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نویسندگان مقاله partha mohanty |
microbiology and molecular biology national jalma institute for leprosy and other mycobacterial diseases agra, india

فرح naaz |
microbiology and molecular biology national jalma institute for leprosy and other mycobacterial diseases agra, india

آوی کومار bansal | kumar bansal
medical division national jalma institute for leprosy and other mycobacterial diseases agra, india

umesh datta گوپتا | datta gupta
national jalma institute for leprosy and other mycobacterial diseases agra, india

نشانی اینترنتی http://mbrc.shirazu.ac.ir/article_4084_174d58537649d4eeafccdf1e01cb00ea.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/526/article-526-432921.pdf
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زبان مقاله منتشر شده en
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