این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۳، صفحات ۲۴۲-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی α-Lipoic Acid Mitigates Arsenic-Induced Hematological Abnormalities in Adult Male Rats
چکیده انگلیسی مقاله Background: Arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. The present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ALA) against such hematological disorders. Methods: Twenty-four adult male Wister rats (b.wt.130±10g) were grouped and accordingly group I (control) received the normal diet, group II (treated) was given arsenic orally for 28 consecutive days as arsenic trioxide (3 mg/kgbw/rat/day) whereas group III (supplemented) received the same dose of arsenic along with ALA (25 mg/kgbw/rat/day) as oral supplement. Hematological profile, plasma oxidant/antioxidant status, and erythrocyte morphology were assessed. Statistical analysis was done by one-way ANOVA using SPSS software (version 16.0). Results: Arsenic exposure caused reduction of erythrocyte (P=0.021), leucocyte (P< 0.001), and hemoglobin (P=0.031) associated with echinocytic transformation as evidenced by light and scanning electron microscopic studies. The other significantly altered parameters include increased mean corpuscular volume (P=0.041) and lymphocytopenia (P< 0.001) with insignificant neutropenia and eosinophilia. Altered serum oxidative balance as evidenced by decreased TAS (P< 0.001) and increased TOS (P< 0.001) with OSI (P< 0.001) was also noted. The dietary supplementation of ALA has a beneficial effect against the observed (P< 0.05) arsenic toxicities. It brings about the protection by restoring the hematological redox and inflammatory status near normal in treated rats. Arsenic-induced morphological alteration of erythrocytes was also partially attenuated by ALA supplementation. Conclusion: It is concluded that arsenicosis is associated with hematological alterations and ALA co-supplementation can partially alleviate these changes in an experimental male rat model.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله sonali ghosh | sonali ghosh
department of physiology, university of calcutta, kolkata, india; and department of physiology, ananda mohan college, university of calcutta, kolkata, india;


raghwendra میشرا | raghwendra mishra
department of biological sciences, presidency university, kolkata, india;


sagnik biswas | sagnik biswas
department of infectious diseases amp; immunology, csir-indian institute of chemical biology, kolkata, india


rupak k bhadra | rupak k bhadra
department of biological sciences, presidency university, kolkata, india;


prabir کومار mukhopadhyay | prabir kumar mukhopadhyay


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2861
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-433414.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article(s)
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات