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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۳، صفحات ۳۱۸-۰
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عنوان انگلیسی High-Grade Urothelial Carcinoma of Bladder Transforming to Micropapillary Variant on Follow-Up
چکیده انگلیسی مقاله Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinoma and returned with recurrence after 16 months. Histopathology after transurethral biopsy revealed a non-muscle invasive high-grade bladder tumour at first presentation, whereas tumour recurrence was reported after 1.5years. The histopathology at recurrence revealed a high-grade, muscle invasive, micropapillary variant of urothelial carcinoma with focal adenomatous morphology. Immunohistochemical expression of CK7 + /CK20 + in tumour cells and negativity for PSA, AMACR, and CDX2 in paraffin section helped in identifying the tumour as primary in the urinary bladder. Radical cystectomy was performed and the patient has no distant metastases on follow-up. The specific morphology even within the high-grade urothelial cancer cases is important to discern for proper treatment.
کلیدواژه‌های انگلیسی مقاله Transitional cell carcinoma, Micropapillary variant, Bladder
نویسندگان مقاله nitu kumari | nitu kumari
national institute of pathology, indian council of medical research, new delhi, india


anupama jha | anupama jha
deptt of urology, vmmc and safdarjung hospital, new delhi, india


pawan vasudeva | pawan vasudeva
national institute of pathology, indian council of medical research, new delhi, india


اوشا آگرووال | usha agrawal


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2504
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-433440.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report(s)
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