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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۱، صفحات ۷۳-۰
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عنوان انگلیسی Effect of Melatonin on the Outcome of Assisted Reproductive Technique Cycles in Women with Diminished Ovarian Reserve: A Double-Blinded Randomized Clinical Trial
چکیده انگلیسی مقاله Diminished ovarian reserve (DOR) significantly decreases the success rate of the assisted reproductive technique (ART). In this study, we assessed the effect of melatonin on the ART outcomes in women with DOR. A double-blinded, randomized, clinical trial was performed on 80 women with DOR as a pilot study in Shiraz, between 2014 and 2015. DOR was defined as the presence of 2 of the following 3 criteria: 1) anti-Müllerian hormone ≤1, 2) folliclestimulating hormone ≥10, and 3) bilateral antral follicle count ≤6. The women received 3 mg/d melatonin or a placebo since the fifth day of one cycle prior to gonadotropin stimulation and continued the treatment up to the time of ovum pickup. The ART outcomes were compared between the groups using SPSS software. Finally, there were 32 women in the case and 34 in the placebo groups. The mean age and basal ovarian reserve test were the same between the groups. The serum estradiol level on the triggering day was significantly higher in the case group (P=0.005). The mean number of MII oocytes was higher in the case group, but the difference did not reach statistical significance. Number of the patients who had mature MII oocytes (P=0.014), top-quality embryos with grade 1 (P=0.049), and embryos with grades 1 and 2 (P=0.014) was higher among the women who received melatonin. However, the other ART outcomes were not different between the groups. The serum estradiol level was higher and more women with DOR had good-quality oocytes and embryos after receiving melatonin; however, no other outcome was different between the case and control groups. Trial Registration Number: IRCT2014041417264N1
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نویسندگان مقاله بهیه نام آور جهرمی | bahia namavar jahromi
department of obstetrics and gynecology, school of medicine, shiraz university of medical sciences, shiraz, iran; and student research committee, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

سارا صادقی | sara sadeghi
department of pharmaceutics, department of pharmaceutical quality control, school of pharmacy, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

شهره علیپور | shohreh alipour
infertility research center, shiraz university of medical sciences, shiraz, iran; and department of obstetrics and gynecology, school of medicine, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمد ابراهیم پارسانژاد | mohammad ebrahim parsanezhad
department of obstetrics and gynecology, school of medicine, shiraz university of medical sciences, shiraz, iran; and student research committee, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

شقایق مرادی علمدارلو | shaghayegh moradi alamdarloo


نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2032
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-433444.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Brief Report(s)
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