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Basic and Clinical Cancer Research، جلد ۸، شماره ۱&۲، صفحات ۴-۱۷
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عنوان انگلیسی interaction of estrogen and progesterone receptors, and human epithelial receptor 2, with breast cancer risk factors: a multi-center case-only study in iran
چکیده انگلیسی مقاله BACKGROUND: The etiology of breast cancer and our understanding on the carcinogenicity of different risk factors is impotant for control programms. OBJECTIVE: We investigated the expression of estrogen and progesterone receptors (ER, PR), and human epithelial receptor 2 (HER2) overexpression and its associations, with environmental risk factors among breast cancer patients. METHODS: We classified the patients into four groups including; triple negative (ER–/PR–/HER2-), HER2-overexpression (ER–/PR–/HER2+), luminal A (ER+ and/or PR+/HER2-) and luminal B (ER+ and/or PR+/HER2+). We used a case-only design and multinomial logistic regression analyses. RESULTS: In premenopausal patients, those with high BMI had lower prevalence of luminal B tumors compared to luminal A groups (OR= 0.42, 95% CI= 0.23 to 0.74). However, in the postmenopausal groups, prevalence of the luminal B tumors was less than luminal A tumors oral contraceptive pill (OCP) users (OR= 0.64, 95% CI= 0.42 to 0.98). In addition, among those who had an older age at menarche had a higher risk of ER2-overexpression tumors compared to luminal A tumors (OR= 2.82, 95% CI= 1.29-6.19). CONCLUSIONS: Expression of HER2, ER, and PR, among breast cancer patients seems to be associated with OCP use, BMI, age at menarche and age at first pregnancy.
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نویسندگان مقاله رحیم اکرمی | rahim akrami
cancer research center, cancer institute of iran, tehran university of medical sciences, iran department of biostatistics, institute of basic medical sciences, university of oslo, oslo, norway

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رضا غیاثوند | reza ghiasvand
department of epidemiology amp; biostatistics, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اکبر فتوحی | akbar fotouhi
cancer research center, cancer institute of iran, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ایرج حریرچی | iraj harirchi
research center for health sciences, department of epidemiology, school of health and nutrition, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

عباس رضاییان زاده | abbas rezaianzadeh
breast diseases research group, breast cancer research center , acecr


عبدالرسول طالعی | abdolrasoul talei
breast diseases research group, breast cancer research center , acecr


آسیه الفت بخش | asiie olfatbakhsh
associated professor of radiation oncology, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فاطمه همایی شاندیز | fatemeh homaei shandiz
cancer research center, cancer institute of iran, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کاظم زنده دل | kazem zendehdel


نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/197
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/151/article-151-433597.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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