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Basic and Clinical Cancer Research، جلد ۸، شماره ۱&۲، صفحات ۴۲-۴۹
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عنوان انگلیسی Long ُُStress-induced Non-coding Transcript 5 rs2935641 Polymorphism and the risk of Bladder Cancer in Patients from Fars Province
چکیده انگلیسی مقاله Background: Bladder cancer is one of the most common cancers in the world with considerably higher frequency among men than women. Treatment of the disease is possible according to early diagnosis, so identifying useful markers is very important. LSINCT5 (long stress-induced non-coding transcript 5) is a stress-regulated lncRNA involved in response to oxidative stress, also in cell proliferation and cancer development, especially in the presence of tobacco carcinogens. Objective: in this study, we aimed to evaluate the influence of LSINCT5 gene polymorphism with the susceptibility of bladder cancer among a group of patients from south of Iran. Methods: 100 patients with bladder cancer and 100 healthy subjects as control group were investigated in this case-control study. Genotyping of the rs2935641 polymorphism was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Results: It was found that the single base substitution C to T at the coding region of the LSINCT5 was not significantly associated with bladder cancer. Genotype and allele frequencies distributed evenly among cases and controls, but no TT genotype was seen. History of smoking was significantly higher in bladder cancer patients compared to controls (p< 0.001). Conclusion: Results showed that the LSINCT5 polymorphism was not a key factor in the pathogenesis of bladder cancer. Tobacco smoking is one of the strongest risk factors for bladder cancer.
کلیدواژه‌های انگلیسی مقاله Bladder cancer,LSINCT5,LncRNA,Polymorphism
نویسندگان مقاله محبوبه نصیری | mahboobeh nasiri
department of biology, islamic azad university, arsanjan branch, arsanjan, iran. young researchers and elite club, islamic azad university,arsanjan branch, arsanjan, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

عباس قادری | abbas ghaderi
shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/193
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/151/article-151-433602.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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