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Iranian Journal of Public Health، جلد ۴۳، شماره ۵، صفحات ۶۳۰-۶
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عنوان انگلیسی Association of Tumor Necrosis Factor Alpha Gene Polymorphisms with Inflammatory Bowel Disease in Iran.
چکیده انگلیسی مقاله Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology, in which genetic factors, seem to play an important role in the disease predisposition and course. Assessment of tumor necrosis factor (TNF-α) gene polymorphisms in many populations showed a possible association with IBD. Considering the genetic variety in different ethnic groups, the aim of the present study was to investigate the association of five important single nucleo-tide polymorphisms (SNPs) in the promoter region of (TNF-α) gene with IBD in Iran.In this case-control study, 156 Ulcerative colitis (UC) patients, 50 Crohn's disease (CD) patients and 200 sex and age matched healthy controls of Iranian origin were enrolled. The study was performed during a two year period (2008-2010) at Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. DNA samples were evaluated for (TNF-α) gene polymorphisms (including -1031, -863, -857, -308 and -238) by PCR and RFLP methods.The frequency of the mutant allele of -1031 polymorphism was significantly higher in Iranian patients with Crohn's disease compared to healthy controls (P=0.01, OR=1.92; 95% CI: 1.14-3.23). None of the other evaluated polymorphisms demonstrated a significant higher frequency of mutant alleles in Iranian IBD patients compared to controls.Among the five assessed (SNPs), only -1031 polymorphism of (TNF-α) gene may play a role in disease susceptibility for Crohn's disease in Iran. This pattern of distribution of (TNF-α) gene polymorphisms could be specific in this population.
کلیدواژه‌های انگلیسی مقاله Crohn’s disease,SNPs,TNF-α gene,Ulcerative colitis
نویسندگان مقاله دکتر نصرت اله نادری | nosratollah naderi
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

دکتر آلما فرنود | alma farnood
2. imam khomeini hospital, tehran university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

طاهره دادایی | tahereh dadaei
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

منیژه حبیبی | manijeh habibi
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

هدیه بالایی | hedie balaii
2. imam khomeini hospital, tehran university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

دکتر فرزاد فیروزی | farzad firouzi
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

آیدین مهبان | aydin mahban
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

معصومه سلطانی | masoumeh soltani
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

محمدرضا زالی | mohammadreza zali
1. gastroenterology and liver disease research center, shahid beheshti university of medical science , tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/4093
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