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Basic and Clinical Cancer Research، جلد ۳، شماره ۳&۴، صفحات ۳۰-۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Mouse spontaneous mammary adenocarcinoma as a suitable model of breast cancer in Iran
چکیده انگلیسی مقاله Background : Breast cancer is a complicated disease and has various clinical manifestations and prognosis. The aim of this study is to make a breast cancer model suitable for basic, preclinical and clinical studies. Materials and methods: Five virgin Bulb/c mice aged 6 weeks and spontaneous Murine Mammary Adenocarcinoma Cells (MMAC) were used. After anesthesia induction, 1-3 million of MMACs were subcutaneously injected into the mice’s right flank. Four weeks after the tumor induction, tumor size in both length and width were weekly measured using caliper for 4 weeks. Histopathology studies were done 2 months later by Scraff- Boom-Richardson grading. Results: Visible tumors were appeared after 4 weeks. Take-rate of all cells was nearly 100%. Tumor sizes reached 0.6±0.1 mm 3 , 1.1±0.3, 1.68±0.5 and 3±0.7 cm 3 with at fifth, sixth, seventh and eighth weeks respectively. The histopathological studies using H & E method showed invasive ductal carcinoma, grade II/III. Conclusions: Elucidation of the molecular mechanisms of breast cancer progression and metastasis has extremely gained from mouse models in which some stages of tumor progression are recapitulated.
کلیدواژه‌های انگلیسی مقاله Mice,adenocarcinoma model,breast cancer
نویسندگان مقاله علی محمد علیزاده | ali mohammad alizadeh
cancer research center, tehran university of medical science, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

صالح عزیزیان | saleh azizian
azad islamic university-varamin pishvar branch, varamin, i.r. iran


حمیدرضا فیاضی | hamid reza fayazi
cancer research center, tehran university of medical science, tehran, i.r. iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

مریم سادات موسوی | maryam sadat mousavi
azad islamic university-varamin pishvar branch, varamin, i.r. iran


سید علی نبوی | seyed ali nabavi


نشانی اینترنتی http://bccr.tums.ac.ir/index.php/bccrj/article/view/35
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/151/article-151-433664.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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