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Iranian Journal of Public Health، جلد ۴۲، شماره ۵، صفحات ۵۲۹-۵۳۳
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عنوان انگلیسی Immunoglobulin A Nephropathy and Malaria falciparum Infection; a Rare Association.
چکیده انگلیسی مقاله Glomerular involvement occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Here, we report a rare case of falciparum malaria-associated IgA nephropathy. A 28-year-old man was admitted because of fever and abdominal pain. Ultrasound and computed tomography (CT) showed right kidney pyonenphrosis. Despite placing a nephrostomy tube, fever continued. Repeated CT was in favor of focal pyelonephritis. In addition, peripheral blood smear suggested malaria. Anti-malarial drugs were initiated and right nephrectomy was performed. One year after recovery from malaria, a persistent rise in serum creatinine was detected. A left kidney biopsy showed mesangial proliferation and dominant IgA deposits in immunofluorescence study while C1q was not deposited. The impression was IgA nephropathy with M1E0S0T0 of Oxford classification. The patient was prescribed a combination of low dose prednisolone and angiotensin converting enzyme inhibitor. Six months after treatment serum creatinine decreased from 1.6 mg/dL to 1.3mg/dL and urine abnormalities were disappeared. Our findings suggest that malaria infection might be associated with IgA nephropathy.
کلیدواژه‌های انگلیسی مقاله IgA nephropathy,Malaria,Plasmodium falciparum
نویسندگان مقاله محمود رفیعیان کوپایی | mahmoud rafieian kopaei
medical plants research center, shahrekord university of medical sciences, shahrekord, iran.


حمید نصری | hamid nasri


فرشید علیزاده | farshid alizadeh


بهروز عطایی | behrooz ataei


آذر برادران | azar baradaran


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/4534
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