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Journal of Craniomaxillofacial Research، جلد ۴، شماره ۳، صفحات ۳۸۳-۳۸۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Gene therapy a new approach in dentistry: human or microbial gene modification
چکیده انگلیسی مقاله Introduction : This review provides an update on transfer techniques and clinical implications of gene therapy in dentistry. Gene therapy is a new biomedicine emerging field that manipulates genes to achieve gain function in patient cells. Gene therapy essentially consists of introducing specific genetic material into target cells to compensate for abnormal genes or to make a beneficial protein without producing toxic effects on surrounding tissue. Gene therapy can be used to treat wide range of diseases ranging from single gene disorder to multi gene disorder. It has variety of applications in the field of dentistry like in periodontal disease, cancerous and precancerous condition, salivary gland disorders, autoimmune diseases, bone repair, DNA vaccination, etc. Minor salivary glands and keratinocytes present in the oral mucosa are excellent target sites for gene therapy since it can be readily accomplished with minimal invasive manner. As a new aspect scientists investigating for tooth regrown using shark gene network activation in human cells. Applications of gene therapy to dental and oral problems illustrate the potential impact of this technology on dentistry. Aim of this article is to description in brief on the application, limitation and disadvantage of gene therapy in dentistry. Key words : Gene therapy, Dentistry, Viral vector, Stem cell.
کلیدواژه‌های انگلیسی مقاله Gene therapy,Dentistry,Viral vector,Stem cell.
نویسندگان مقاله مهران مرادی فارسانی | mehran moradi farsani
craniomaxillofacial research center, tehran university of medical sciences, tehran, iran. oral and maxillofacial surgery department, school of dentistry, tehran university of medical sciences, tehran, iran. iranian tissue bank amp; research center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نغمه بهرامی | naghmeh bahrami
cell therapy center, gandhi hospital, tehran, iran.


سحر شجاعی | sahar shojaei


نشانی اینترنتی http://jcr.tums.ac.ir/index.php/jcr/article/view/169
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/364/article-364-439184.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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