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Iranian Journal of Public Health، جلد ۳۸، شماره ۲، صفحات ۳۷-۴۳
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عنوان انگلیسی Immunohistochemistry Analysis of P53 and Ki-67 Proteins in Oral Lichen Planus and Normal Oral Mucosa
چکیده انگلیسی مقاله Background: Oral lichen planus (OLP) is a relatively common chronic inflammatory muco-cutaneous disease classified among the potentially malignant lesions of oral mucosa. In this study we evaluated tissue expression of p 53 ، ki-67 in OLP com­pared to normal oral mucosa. Methods: Specimens (formalin-fixed and paraffin- embedded) of 44 lesions of OLP and 30 controls referred to immuno­histochem­istry (IHC) analysis for p 53 and ki-67. Results of immunohistochemistry were statistically evaluated by means of Kolmogorov- Smirnov, Kruskal- Wallis and t -test. The level of statistical significance was established at P < 0.05. Results : This study included 44 patients with OLP (27 females and 17 males) and 30 subjects as control group (18 females and 12 males).The mean expression of p 53 in patients with OLP was greater than subjects in control group. The mean expres­sion of ki- 67 in patients with OLP was more than people in control group. These differences were statistically signifi­cant ( P = 0.001). Conclusion: Since p 53 and ki-67 extensively accepted as important biomarkers in diagnosis, prognosis and treatment of malig­nant and premalignant lesions, therefore high degree of presence of these biomarkers in chronic premalignant lesion like OLP can be a great helpful in its prognosis and suggested treatments.
کلیدواژه‌های انگلیسی مقاله Oral lichen planus, Immunohistochemistry, P53, ki-67
نویسندگان مقاله f آقا حسینی | f agha hosseini
dept. of oral medicine, faculty of dentistry, dental research center, tehran university of medical s

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

خلیلی | m khalili
dept. of oral pathology, faculty of dentistry, dental research center, tehran university of medical

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

b روحانی | b rohani
dept. of oral medicine, faculty of dentistry, dental research center, tehran university of medical s

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/3187
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