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Iranian Journal of Public Health، جلد ۳۷، شماره ۴، صفحات ۲۶-۳۱
عنوان فارسی
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عنوان انگلیسی The Evaluation of Matching in a Case-Control Study of Colorectal Cancer Using General Practice Lists
چکیده انگلیسی مقاله Background: A crucial part of a case-control study is the selection of a sample of controls that represent the base-popula­tion from which cases were drawn. Controls may be matched to cases by one or more potentially important confounding vari­ables, such as socioeconomic status. In the United Kingdom, one method for control selection has been based on the pa­tient list of the General Practice with whom the cases were registered, which we refer to as GP-matching. We aimed to ex­plore whether GP-matching adequately control for the potential confounding effect of socioeconomic status. Methods: The Townsend index of deprivation was calculated for different two national census geography levels of Elec­toral ward/Postcode Sector and Enumeration District/Output area for the three study areas of Dundee, Leeds and York. Con­ditional logistic regression was used to estimate the association of cases with deprivation (based on the Townsend index) com­pared with that of matched controls for the two geographical scales. Results: At the largest geographical level (Electoral ward/Postcode Sector) there was no evidence of a difference in the dis­tribution of deprivation scores between cases and controls. However, analysis at the smallest level (Enumeration Dis­trict/Output area) showed that, despite GP matching, cases were more likely to live in deprived areas than matched controls. Conclusion: Using General Practice lists for the selection of controls for controlling the confounding effect of socioeco­nomic status might not be an appropriate method for case-control studies conducted in the United Kingdom.
کلیدواژه‌های انگلیسی مقاله Case-control study, Confounding, Townsend deprivation index
نویسندگان مقاله m موحدی | m movahedi
dept. of epidemiology, school of public health, shaheed beheshti university of medical sciences, te

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

t پیشاب | t bishop
genetic epidemiology unit, cancer research uk, st.james hospital, beckett street, ls9 7ft, leeds,


jh بارت | jh barrett
genetic epidemiology unit, cancer research uk, st.james hospital, beckett street, ls9 7ft, leeds,


gr لاو | gr law
centre for epidemiology and biostatistics, university of leeds, 30 hyde terrace, leeds, ls2 9ln, uk
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2010
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زبان مقاله منتشر شده en
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