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Iranian Journal of Public Health، جلد ۳۷، شماره ۴، صفحات ۵۲-۵۸
عنوان فارسی
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عنوان انگلیسی Frequency and Antimicrobial Susceptibility of Haemophilus influenzae Type b Isolated from Children Suspected to Meningitis
چکیده انگلیسی مقاله Background: Haemophilus influenzae type b (Hib) has emerged as the predominant cause of meningitis in developing coun­tries wherever it has been studied using good microbiologic procedures, but data regarding frequency, antimicrobial sus­ceptibility and preferable method for detection of Haemophilus influenzae type b isolated from Iranian patients were scarce. Methods: One thousand and eight hundred suspicious CSF samples were received from Children Medical Center Hospital in Tehran, periodically. All samples were cultured on conventional and selective media for Haemophilus influenzae type b de­tection. PCR performed for samples were Hib negative in culture. The susceptibility of the isolates to different an­timicrobial agents was determined using the disk diffusion method. Results: Overall, 6.7% (n= 121) of specimens had positive culture. 15.7% (n= 19) of isolates were diagnosed as Hae­mophilus influenzae type b with both culture and Antiserum test. PCR assay detected 10 isolates of H. influenzae type b in sam­ples weren't detected in culture. H. influenzae type b isolates were resistance to ampicillin (42.1%), chloramphenicol (36.8%), and co-trimoxazole (52.6%), respectively. The range of antimicrobial susceptibility to cephalosporins was from 52.6% for cephalothin to 57.8% for ceftriaxone, ceftazidime, cefixime and ceftizoxime. Multidrug resistances were ob­served in 31.5% of H. influenzae type b isolates. Conclusion: Although we found high frequency of resistance to the first line drugs for H. influenzae type b in Iran, but the fre­quency of this organism among children meningitis was lower than many Asian and European countries. PCR assay was more sensitive in detection of H. influenzae than culture method.
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نویسندگان مقاله mt haghiashteiani | mt haghiashteiani
dept. of pathology, cmc hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s محمدی یگانه | s mohammadi yeganeh
dept. of microbiology, school of medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s سروش | s soroush
dept. of microbiology, school of medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n صادقی فرد | n sadeghifard
dept. of microbiology, school of medicine, ilam university of medical science, iran

سازمان اصلی تایید شده: دانشگاه ایلام (Ilam university)

سیروس صیادی | s sayadi
dept. of microbiology, school of medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h dabyri | h dabyri
dept. of microbiology, school of medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عابدینی | m abedini
laboratory of cmc hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m طاهری کلانی | m taherikalani
dept. of microbiology, school of medicine, ilam university of medical science, iran

سازمان اصلی تایید شده: دانشگاه ایلام (Ilam university)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2014
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