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Iranian Journal of Public Health، جلد ۳۷، شماره ۳، صفحات ۱۱۸-۱۲۶
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عنوان انگلیسی Homocysteine in Gestational Diabetes and Normal Pregnancy plus Effects of Folic Acid
چکیده انگلیسی مقاله Background: The aim of study was to assess serum homocysteine and its relation with serum folate, vit B12 and lipid pro­files in gestational diabetes mellitus and comparison with normal pregnant women as well as effect of different doses of fo­lic acid on Homocysteine (Hcy) and pregnancy outcome. Methods: In a biphasic study first prospective controlled study 80 pregnant women were chosen at 24-28 weeks of gesta­tion. In case group pregnant women with gestational diabetes mellitus and control group who had normal Oral Glucose Toler­ance test (GTT) results. Levels of fasting glucose, homocysteine, vit B12, and folic acid, uric acid, total cholesterol, triglyc­eride, LDL, HDL, were measured. In phase II study a randomized clinical trial was done with diabetic women 15 with 1mg folic acid and 15 with 5 mg folic acid for six weeks and then above variables and pregnancy outcome was evalu­ated. Results : The mean levels of homocysteine in Gestational Diabetes Mellitus (GDM) group were significantly higher but fo­lic acid and vit B12 were significantly lower. Hcy levels were decreased in both groups after six weeks folic acid but de­crease in Hcy for group 5mg was significantly more than 1mg group. Conclusion : Homocysteine levels were higher in GDM than normal pregnancy. High dose folic acid can reduce Hcy levels more than low dose and it may be a safe, simple, inexpensive intervention that prevents major pregnancy complications.
کلیدواژه‌های انگلیسی مقاله Homocysteine, Gestational diabetes, Pregnancy outcome
نویسندگان مقاله f داوری تنها | f davari tanha
dept. of obstetrics amp;amp; gynecology, mirza kochak khan hospital, tehran university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f خان محمدی | f khan mohamadi
dept. of obstetrics amp;amp; gynecology, mirza kochak khan hospital, tehran university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m کاوه | m kaveh
dept. of obstetrics amp;amp; gynecology, mirza kochak khan hospital, tehran university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m شریعت | m shariat
dept. of obstetrics amp;amp; gynecology, mirza kochak khan hospital, tehran university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2044
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