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Iranian Journal of Public Health، جلد ۳۷، شماره ۳، صفحات ۱۴۲-۱۴۵
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عنوان انگلیسی Humoral Immune System Alterations in Silica Exposed Workers
چکیده انگلیسی مقاله Background: Crystalline silica may act as an immune adjuvant to increase inflammation and antibody production. The high­est exposures to silica are known to occur in the dusty trades industries such as stone- cutting. We undertook this popula­tion based study to examine the association between occupational silica exposure and humoral immune system. Methods: In this historical cohort study, 47 workers from 10 stone-cutting factories in Rey City, south of Tehran, Iran that had more than 10 years exposure to silica were included in case group and 45 individual without any exposure to silica were selected for control group. We measured serum immunoglobulins (IgM, IgG, and IgA) of participants with ELISA method and compared the results between exposed workers and control groups. Results: The mean concentrations of two immunoglobulines (IgG, IgA) and IgM in case group in comparison with control group were higher and lower respectively but both were in normal range. IgA concentration between two groups was statisti­cally significant ( P < 0.05). Conclusion: Crystalline silica exposure may promote the humoral immune system in some individuals. Additional research is recommended in other population, using study design that minimize potential selection bias and maximize the quality of expo­sure assessment.
کلیدواژه‌های انگلیسی مقاله Silica, Humoral immunity, Stone-cutting, Iran
نویسندگان مقاله o امینیان | o aminian
dept. of occupational medicine, school of medicine, tehran university of medical sciences, iran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

sa شریفیان | sa sharifian
dept. of occupational medicine, school of medicine, tehran university of medical sciences, iran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

r مهرداد | r mehrdad
dept. of occupational medicine, school of medicine, tehran university of medical sciences, iran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h kaht narooey | h kaht narooey
baharloo hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

o گیاهی | o giahi
dept. of occupational medicine, school of medicine, tehran university of medical sciences, iran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2047
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