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Iranian Journal of Public Health، جلد ۳۷، شماره ۳، صفحات ۱۴۶-۱۵۲
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عنوان انگلیسی Hepatitis C Virus Infection and HCV Genotypes of Hemodialysis Patients
چکیده انگلیسی مقاله Background: To evaluate the prevalence of hepatitis C by antibody testing, HCV-RNA detection by PCR and relative risk fac­tors of HCV infection among HD patients and staff members in Markazi Province/Iran. The other purpose was to deter­mine genotypes of HCV in this population. Methods: The study group consisted of 204 HD patients and 47 staff members from all 9 dialysis centers in Markazi Prov­ince, Iran. Anti-HCV antibodies were tested using a third generation ELISA and confirmed by RIBA. HCV RNA was deter­mined by RT-PCR and genotyping was performed by a reverse hybridization assay (LiPA). Results: The overall prevalence of HCV (HCV antibody and HCV-RNA) was 5.4%. Female sex ( P = 0.019), duration of dialy­sis ( P = 0.003) and kidney transplant ( P = 0.049) were significantly correlated with HCV infection. The predominant sub­type was HCV-1a, detected in 4(50%) of the 8 HD patients. Genotype 4, 3a and 1b were found in 2(25%), 1(12.5%) and 1(12.5%) patients respectively. The prevalence of anti-HCV among staff members of HD units was 0%. Conclusion: The presence of anti HCV positive patients who had never been transfused, high prevalence of genotype 4 in this population, duration of HD as a risk factor for HCV positivity and non significant association between blood transfu­sion and HCV infection suggest nosocomial transmission of the virus in dialysis units that needs to be confirmed by phyloge­netic analysis of subgenomic regions of HCV. HD staff members dose not seem to be at increased risk of hepatitis C de­spite the frequent blood exposure and lack of strict adherence to universal infection control precautions.
کلیدواژه‌های انگلیسی مقاله Hepatitis C virus, Hemodialysis, HCV genotypes, Iran
نویسندگان مقاله k صمیمی راد | k samimi rad
dept. of virology, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

 سید مصطفی حسینی | m hosseini
dept. of epidemiology and biostatistics, school of public health, tehran university of medical scien

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

b شهباز | b shahbaz
dept. of virology, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2048
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