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Iranian Journal of Public Health، جلد ۳۷، شماره sup، صفحات ۷-۱۵
عنوان فارسی
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عنوان انگلیسی Osteoimmunological Insight in to Vertebral Fractures in Osteoporosis
چکیده انگلیسی مقاله Background: The aim of this study was to investigate the relationship among circulating levels of OPG, RANKL, cytokine profiles, bone mineral density (BMD) and vertebral fractures in pre and postmenopausal women and comparing these find­ing in three groups including osteoporotic patients with and without fracture and healthy women. Methods: In a cross-sectional study, 215 women who attended the BMD unit of Endocrinology & Metabolism Research Center (EMRC) of Tehran University of medical sciences were recruited. Serum Osteoporotegerin and sRANKL were measured. In addition, cytokines profile evaluated. Lumbar radiographs in the antero-posterior and left lateral projections were acquired following a standardized protocol and bone mineral densitometry was performed. Results: In X-ray study, 65.2% of postmenopausal women and 34.8% of pre menopausal women had at least one vertebral fracture ( P = 0.04). Serum OPG and TNFα concentration significantly correlated with age (OPG: P = 0.001, r= 0.22, TNFα: P =0.04, r= 0.15). In logistic regression model, RANKL/OPG ratio independent of age and BMD was predicted vertebral fractures. Conclusion: Osteoimmunological insight in to vertebral fracture indicated that important role of proinflammatory cytokines and RANKL/OPG pathway in bone remodeling .
کلیدواژه‌های انگلیسی مقاله Vertebral fractures, Osteoprotegerin, RANKL, Bone turnover
نویسندگان مقاله h ثقفی | h saghafi
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a حسین نژاد | a hossein nezhad
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

n صدیقی | n sedighi
radiology department of shariati hospital, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

p توفیقی | p tofighi
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سلطانی | a soltani
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b لاریجانی | b larijani
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

r حافظی | r hafezi
physical medicine amp;amp; rehabilitation, baghiatallah university of medical sciences, tehran, iran
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2892
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